Skip to main content
OpenTrials
Completed

NCT Number: NCT05542641

T-mult: Exploring the Impact of TMS Induced Virtual Lesions on the Multimodal Brain Network and Cognition

T-mult is an experimental study using low-frequency (1Hz) single-sesson rTMS to the DLPFC (versus sham rTMS) to explore the effect of virtual lesions on the brain network and cognition in 100 healthy adults (20-65 years old).

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Healthy Cognition

Age range

20 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

VU University Medical Centers, location VUmc

Amsterdam, 1081 HV, Netherlands

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 20 and 65 years old
  • Native Dutch speaker
  • Able to provide written informed consent

Exclusion criteria

  • History of diagnosed neurological or psychiatric disease (including traumatic head injury)
  • Current and regular use of centrally acting drugs (recreational or prescribed, including analgesics), including the use of alcohol ~8 hours prior to an appointment
  • Presence of any contraindications for MRI, MEG, or TMS (including resting motor threshold >75% of maximum stimulator output or no useful motor-evoked potential elicitable)
  • Previous rTMS treatment

Treatment and study plan

Repetitive transcranial magnetic stimulation (rTMS)

Device

real versus sham rTMS

Primary outcomes

  1. Cognitive change

    Time frame: baseline versus directly post-intervention (max. 8 weeks after baseline)

    Change in performance on a neuropsychological test measuring cognitive functioning in the domain of executive functioning

Secondary outcomes

  1. Brain network change

    Time frame: baseline versus directly post-intervention (max. 8 weeks after baseline)

    Change in brain network organization as characterised by multimodal neuroimaging

Sponsors and collaborators

Lead sponsor

Amsterdam UMC, location VUmc

Other

Registry information

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
Sep 15, 2022
Registry last updated
May 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.