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Completed

NCT Number: NCT02998346

Systemic Metabolic Contribution From Continuous Renal Replacement Therapy (CRRT)

The purpose of this observational study is to measure the number of calories delivered from fluids used in continuous renal replacement therapy (CRRT). We are doing this research study because the fluids used in this treatment may deliver an important number of calories. In the future this could help better estimate how much nutrition patients in the Critical Care Unit should get every day from other sources like tube feeding or nutrition through a person's veins.

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Key information

Conditions

Acute Kidney Injury Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Kidney Diseases Male Urogenital Diseases Renal Insufficiency Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

The goal of this study is to quantify the specific metabolic contribution of standard continuous renal replacement protocols (including citrate anticoagulation) in the intensive care unit patient population at Mayo Clinic in Rochester, Minnesota utilizing a prospective, observational study. This data will allow practitioners to better tailor caloric provision with nutrition support programs, minimizing the risk of overfeeding in this complex critical care patient population.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age greater than or equal to 18 years
  • Patients in an intensive care unit anticipated to receive greater than or equal to 24 hours of continuous venovenous hemofiltration.
  • Receiving regional citrate anticoagulation with ACD-A solution.

Exclusion criteria

  • Vulnerable adults
  • Pregnant
  • BMI > 40
  • Patient on extracorporeal membrane oxygenation therapy
  • Reversal of port connections on the dialysis catheter and dialysis circuit lines

Treatment and study plan

Primary outcomes

  1. Quantify net glucose uptake from citrate and dextrose-containing fluids from continuous venovenous hemofiltration

    Time frame: Two days

  2. Quantify net citrate uptake from citrate and dextrose-containing fluids from continuous venovenous hemofiltration

    Time frame: Two days

Sponsors and collaborators

Lead sponsor

Mayo Clinic

Other

Registry information

Official study title

Quantification of Systemic Metabolic Contribution From Continuous Renal Replacement Therapy (CRRT) Utilizing Regional Citrate Anticoagulation

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Dec 20, 2016
Registry last updated
Jan 31, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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