Systemic Inflammation Versus Acute Pain in Total Knee Arthroplasty (TKA)

In this study we evaluate if there is a correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA).

Completed

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Key information

Conditions

Other Acute Postoperative Pain Inflammation Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Shock Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Dep. of Anesthsiology, Hvidovre University Hospital

Copenhagen, Hvidovre, 2650, Denmark

About this study

The correlation between acute pain and systemic inflammatory markers after total Knee Arthroplasty (TKA) is evaluated.

Level of systemic inflammatory markers (CRP and IL6) are measured preoperatively and 4 and 24 hours postoperatively. These measurements are correlated to postoperative pain (a detailed assessment of pain at rest and during ambulation).

We pole blood-samples collected prospectively (from two data set)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Elective unilateral primary total knee arthroplasty
Able to speak and understand danish
Able to give informed consent

Exclusion criteria

Alcohol or medical abuse
Allergies to local anesthetics or methylprednisolone
Age < 18 years old
Daily use of strong opioids or glucocorticoids
Pregnancy or breastfeeding (fertile women)
Bilateral / revision arthroplasty
Dementia or other cognitive dysfunction
Diabetic neuropathy, rheumatoid arthritis, and neurologic or psychiatric diseases potentially influencing pain perception

Treatment and study plan

Primary outcomes

Systemic inflammation vs. pain

Time frame: 1 week

The correlation between pain and systemic inflammatory markers (CRP and IL6)

Sponsors and collaborators

Lead sponsor

Hvidovre University Hospital

Other

Registry information

Official study title

The Relation Between Systemic Inflammatory Markers and Acute Pain in TKA

Important dates

Study start: 2009
Primary completion: 2011
Study completion: 2011
First posted: Mar 24, 2011
Registry last updated: Oct 17, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed