Skip to main content
OpenTrials
Recruiting

NCT Number: NCT06796569

Systemic Immune Inflammatory Index in Systemic Lupus Erythematosus

This study aims to investigate the association between the systemic immune-inflammation index and disease activity, as well as lupus nephritis in patients with systemic lupus erythematosus

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Systemic Lupus Erythematosus Autoimmune Diseases Connective Tissue Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Glomerulonephritis Immune System Diseases Kidney Diseases Lupus Erythematosus, Systemic Lupus Nephritis Male Urogenital Diseases Nephritis Skin and Connective Tissue Diseases Urogenital Diseases Urologic Diseases

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Sohag Faculty

Sohag, Sohag Governorate, 1670005, Egypt

Location status: Recruiting

Location contact

Shorouk Mohamed abdelmageed, master degree

CONTACT

[email protected]

02+01099082079

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • o Older than 16 years
  • In a patient with SLE, patients who fulfill the criteria of the American College of Rheumatology (ACR) and European League Against Rheumatism (EULAR).
  • In patients with LN, patients whose diagnosis is confirmed by kidney biopsy and pathohistological verification (WHO classification, and the International Society of Nephrology/Renal Pathology Society (ISN/RPS) classification.

Exclusion criteria

  • Patients with other autoimmune rheumatological diseases, lymphoproliferative disorders, malignancies, liver diseases, end-stage kidney disease, diabetic nephropathy, active infections, recent history of blood transfusion and patients with deficiencies in vitamin B12, folate, and iron are excluded from the study.

Treatment and study plan

systemic immune inflammatory index

Diagnostic Test

Systemic immune inflammatory index (SII) is a combination of three hematological parameters (platelets, neutrophils, and lymphocytes) and it is calculated using the following formula: SII = (neutrophil count × platelet count)/lymphocyte count.

Primary outcomes

  1. association of systemic immune-inflammation index (SII) disease activity in systemic lupus erythematosus

    Time frame: baseline

    This study aims to investigate if there is an association between the systemic immune-inflammation index (SII) and disease activity in patients with systemic lupus erythematosus using SLEDAI(systemic lupus erythematosus disease activity index) as a valid index to compare results with

  2. association of systemic immune-inflammation index (SII) and lupus nephritis in patients with systemic lupus erythematosus

    Time frame: baseline

    This study aims to investigate the association between the systemic immune-inflammation index (SII) and lupus nephritis in patients with systemic lupus erythematosus

Study contacts

Contact information is provided by the study sponsor or research team.

Shorouk Mohamed abdelmageed, master degree

CONTACT

[email protected]

02 +01099082079

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Association of Systemic Immune Inflammatory Index with Disease Activity and Lupus Nephritis in Patients with Systemic Lupus Erythematosus

Important dates

Study start
2024
Primary completion
2025
Study completion
2026
First posted
Jan 28, 2025
Registry last updated
Jan 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.