Systematic Screening for Primary Immunodeficiencies in Patients Admitted for Severe Infection in Pediatric Intensive Care Unit

Inclusion criteria

• Inclusion age less than 16 years
• Inclusion age > 3 months of actual age for term infants and > 3 months for former preterm infants.
• Documented severe infection (bacterial, viral, fungal) at the University Hospital Center of Montpellier, Toulouse or Marseille
• Severe infections concerned by the study: any infection requiring hospitalization in pediatric intensive care (more than 24 hours) including:
• meninges or brain lesions, pleuro-pneumopathy, any infection associated with sepsis and/or an opportunistic germ, septic shock, etc.
• Encephalitis and encephalomyelitis of infectious origin
• Child benefiting from a social security system
• Collection of parental/legal representative consent

Exclusion criteria

• Undocumented severe infections
• Acute bronchiolitis
• Children admitted with isolated SRV bronchiolitis without further complications from the infection;
• Previous comorbidity explaining the infection and/or stay in ICU/Continuing Care: Primary or known secondary immune deficiency; burns; risk factors for non-infectious epilepsy (encephalopathy, known epilepsy, head trauma), pneumonia caused by swallowing disorders or tracheotomy or chronic lung disease, asthma, meningitis favored by cochlear implants, breach of blood-brain barrier or neuromeningetic material, deep infection on implanted material or within 48h after surgery, cardiovascular decompensation; any other chronic conditions that may contribute to infection;
• Inability to obtain consent from parents/legal guardians.