Systematic Review of Antiretroviral Treatments for Chronic Hepatitis B (CHB)

The purpose of this study is to support the clinical value of entecavir by assessing the relationship between viral load and histological improvement.

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Key information

Conditions

Hepatitis B, Chronic Blood-Borne Infections Chronic Disease Communicable Diseases DNA Virus Infections Digestive System Diseases Disease Attributes Hepadnaviridae Infections Hepatitis Hepatitis B Hepatitis, Chronic Hepatitis, Viral, Human Infections Liver Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Virus Diseases

Age range

16 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Systematic review of prospective clinical trials

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients with CHB diagnosis and no co-infection with Hep A, Hep C, Hep D, or HIV
Age 16 years or older
No post-transplant patients
RCT, non-randomized trials, prospective cohort studies, prospectively analyses case series published since 2003
At least one arm of trial must include monotherapy with entecavir, lamivudine, tenofovir, adefovir, or telbivudine
Study arms must include at least 10 patients
Follow-up of at least 48 weeks
Published results available in English language

Exclusion criteria

Treatment and study plan

Primary outcomes

Viral load
Histological improvement

Sponsors and collaborators

Lead sponsor

Bristol-Myers Squibb

Industry

Registry information

Official study title

A Systematic Review of Literature on Common Antiretroviral Treatments Against Hepatitis B Virus (HBV)

Important dates

Study start: 2009
Primary completion: 2010
Study completion: 2010
First posted: Jul 1, 2010
Registry last updated: Jul 1, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed