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Completed

NCT Number: NCT03419663

Systematic Review and Meta-analysis of Cereal or Grain Consumption and Gastric Cancer

This project involved a systematic literature review of published trials of cereal or grain in relation to the risk of gastric cancer. Data was extracted from the publications on PubMed, EMBASE, Cochrane Library.A traditional meta-analysis, subgroup analysis, and heterogeneity was conducted on the extracted data.

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Key information

Conditions

Gastric Cancer Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Neoplasms Neoplasms by Site Stomach Diseases Stomach Neoplasms

Sex eligibility

All sexes

Study type

Observational

Primary location

West China Hospital, Sichuan University

Chengdu, Sichuan, 610041, China

About this study

Investigators searched PubMed, EMBASE, Cochrane Library for studies focusing on cereal or grain in relation to the risk of gastric cancer up to October 2017. Summary odd ratios (OR) and 95% confidence intervals (CI) were calculated by using either random effect models or fixed effect models according to the heterogeneity of included studies. Subgroup analysis, heterogeneity, and publication bias were also performed.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • a case-control studies or a cohort study
  • investigate the association between cereal or grain intake and GC occurrence
  • report an odds ratio (OR) or relative risk (RR) with corresponding 95% confidence intervals (CI)
  • provide sufficient data to estimate OR or RR

Exclusion criteria

  • Non-human studies
  • GC mortality-based cohort studies

Treatment and study plan

cereal or grain consumption

Dietary Supplement

intake of cereal, whole grain, refined grain, and other grain of every day

Primary outcomes

  1. the relationship between overall cereal consumption and gastric cancer occurance

    Time frame: up to 2 years

    perform a pooled analysis of included studies with OR through STATA 12.0

Secondary outcomes

  1. the relationship between whole grain and gastric cancer occurance

    Time frame: up to 2 years

    perform a subgroup analysis to summarize the related OR through STATA 12.0

  2. the relationship between refined grain and gastric cancer occurance

    Time frame: up to 2 years

    perform a subgroup analysis to summarize the related OR through STATA 12.0

  3. the relationship between other grain and gastric cancer occurance

    Time frame: up to 2 years

    perform a subgroup analysis to summarize the related OR through STATA 12.0

Sponsors and collaborators

Lead sponsor

West China Hospital

Other

Registry information

Official study title

Cereal or Grain Consumption and Gastric Cancer Risk: a Systematic Review and Meta-analysis of Observational Studies

Acronym: GC

Important dates

Study start
2017
Primary completion
2017
Study completion
2018
First posted
Feb 5, 2018
Registry last updated
Feb 5, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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