Synovitis in Patients With Osteoarthritis

To study synovial membrane (SM) inflammation in suprapatellar fossa in advanced knee osteoarthritis (OA), and to correlate the pathological features with clinical findings.

Completed

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Key information

Conditions

Osteoarthritis, Knee Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Rheumatic Diseases

Age range

55 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The affiliated hospital of Qingdao University

Qingdao, Shandong, 266000, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

patients undergoing elective, unilateral, primary TKA for advanced osteoarthritis.

Exclusion criteria

revisions, bilateral procedures, alcohol or medical abuse, administration of any glucocorticoids during the 3 months prior to surgery, and/or a history of serious cardiac or cerebrovascular problems, severe liver or kidney failure, and/or connective tissue disease including rheumatoid arthritis, ankylosing spondylitis, and systemic lupus erythematosus.

Treatment and study plan

Total knee arthroplasty due to advanced osteoarthritis.

Procedure

Postoperative usage of intravenous methylprednisolone

Primary outcomes

Correlation between pathological features and clinical scores

Time frame: 1 day.
Correlation between pathological features and laboratory index

Time frame: 1 day

Sponsors and collaborators

Lead sponsor

The Affiliated Hospital of Qingdao University

Other

Registry information

Official study title

Correlations Between Microscopic Features of Synovium and Clinical Parameters in Patients With Advanced Osteoarthritis

Important dates

Study start: 2020
Primary completion: 2022
Study completion: 2022
First posted: Nov 15, 2022
Registry last updated: Jan 4, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed