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NCT Number: NCT07142369

Synovial Fluid Withdrawal or PRP Injection For Acute ACL Tears and Cytokines

The purpose of this study is to determine what effects the withdrawal of excess knee joint fluid or the injection of a factor from the blood has on swelling after a sudden anterior cruciate ligament (ACL) rupture of the knee.

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Key information

Conditions

Posttraumatic Osteoarthritis Anterior Cruciate Ligament (ACL) Rupture Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Rheumatic Diseases Rupture Wounds and Injuries

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Rush University Medical Center

Chicago, Illinois, 60612, United States

About this study

The body responds to different stresses by releasing factors in the blood and fluids in response to stressors like injury, surgery or certain treatments. Some of these factors help heal and some make the injury and body swell (inflammation). In this study we want to see if the intervention of withdrawing fluid the knee or the addition of an enriched healing factor called platelet rich plasma (PRP) injected in the knee influences the body to produce healing factors in the knee joint fluid.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18 - 50
  • English-speaking
  • Clinical evidence of ACL rupture with swelling
  • Participant must be undergoing ACL reconstruction surgery

Exclusion criteria

  • Age <18 or >50
  • Presentation >3 weeks after initial injury
  • Previous traumatic ipsilateral (same side) knee injury consistent with chronic ACL tear or prior ACL surgery
  • > Kellgren-Lawrence grade 2 changes on preoperative x-ray
  • History of hemophilia or inflammatory arthropathy (e.g., rheumatoid arthritis)

Treatment and study plan

Synovial Fluid withdrawal at the preoperative clinic visit

Procedure

Synovial Fluid withdrawal at the preoperative clinic visit

Other names: arthrocentesis

Platelet-Rich Plasma (PRP) preparation and injection

Procedure

Platelet-Rich Plasma (PRP) preparation and injection

Other names: platelet rich plasma

Synovial fluid withdrawal at the time of surgery

Procedure

Synovial fluid withdrawal at the time of surgery

3mL synovial fluid withdrawn at the preoperative visit

Procedure

3mL synovial fluid withdrawn at the preoperative visit

Primary outcomes

  1. Concentration of Collagen Type II Cytokine

    Time frame: Enrollment up to surgery

    Breakdown cytokine found in damaged cartilage

Study contacts

Contact information is provided by the study sponsor or research team.

Adam Yanke, MD, PhD

CONTACT

[email protected]

(312) 432-2818

Jorge Chahla, MD, PhD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Rush University Medical Center

Other

Collaborators

  • Arthroscopy Association of North America

Registry information

Official study title

Does Arthrocentesis and PRP For Acute ACL Tears With Hemarthrosis Decrease Inflammatory Cytokines At Time Of Surgery: A Prospective Randomized Control Trial (RCT)

Important dates

Study start
2026
Primary completion
2028
Study completion
2028
First posted
Aug 26, 2025
Registry last updated
Jun 18, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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