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Completed

NCT Number: NCT03128970

Synchronizing Blastocyst in Frozen Embryo Transfer

The aim of the present study is to determine if implantation rate could be increased in women undergoing frozen embryo transfer cycles in case of adjusting their embryo development at hatching stage.

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Key information

Conditions

Embryo Implantation

Age range

19 year–33 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Al-Yasmeen fertility and gynecology center, Banhā, Egypt

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who will agree to participate and assign an informed consent form
  • Only blastocyst transfer FET cycles
  • Patients undergoing FET after their 1st IVF or ICSI cycle with no pregnancy at the fresh transfer
  • Freeze-all cycles due to OHSS
  • Freeze-all cycles due to poor endometrium
  • Age 19-33 at the time of randomization.
  • Their frozen blastocysts are 3 or less grade of expansion.
  • Female with a ≥12 AFCs
  • Endometrial thickness ≥ 8mm at the time of ovulation
  • Women with their male partners will give only fresh semen
  • Women who have no uterine abnormality by ultrasound
  • BMI ≤ 31

Exclusion criteria

  • Cycles undergoing preimplantation genetic diagnosis.
  • Women who have previous two cycles of implantation failure at fresh transfer
  • Women who have previous two FET failed cycles
  • Any uterine pathology (myomas, adenomyosis, endocrinopathies, thrombophilia, chronic pathologies, acquired or congenital uterine abnormalities)
  • Patients with severe endometriosis
  • Presence of uni- or bilateral hydrosalpinx
  • Recurrent pregnancy loss.
  • Any medical condition that affect fertility.

Treatment and study plan

synchronizing blastocysts

Other

transferring frozen/thawed a synchronized blastocysts at hatching stage into female uterus.

Primary outcomes

  1. Ongoing implantation rate

    Time frame: 12 weeks

    ultrasound detection of ongoing gestational sacs with heartbeats after 12 weeks of gestation per transferred embryos

Sponsors and collaborators

Lead sponsor

Al-Yasmeen Fertility and Gynecology Center

Other

Collaborators

  • Ganna Fertility Center

Registry information

Official study title

Synchronizing Blastocyst at Hatching Stage in Frozen Embryo Transfer Cycles

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Apr 25, 2017
Registry last updated
Jun 27, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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