Symplicity China Study

Inclusion criteria

• Aged 18 years or older.
• Patients diagnosed with resistant hypertension or antihypertensive drug intolerance and treated with Symplicity Spyral Renal Denervation System. Resistant hypertension, defined as having an office systolic blood pressure (SBP) ≥140 mmHg despite appropriate lifestyle measures and being treated with three or more antihypertensive medications (including a diuretic) for more than 3 months; or drug intolerance, defined as patients who cannot tolerate medication due to contraindications or adverse effects.
• The patient voluntarily undergoes renal denervation; the patient has been informed of the observational nature of the study; the patient voluntarily provides written informed consent ("Patient Informed Consent Form") and willingly participates in the study.

Exclusion criteria

• At least one main renal artery with a diameter less than 3 mm or greater than 8 mm.
• Presence of fibromuscular dysplasia.
• Renal artery stent placement within 3 months prior to the procedure.
• Presence of Renal artery aneurysms.
• Presence of more than 50% stenosis in any treatable vessel.
• Pregnant.
• Present of renal or adrenal tumors.
• Iliac/femoral artery stenosis prevents catheter insertion.