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NCT Number: NCT06787066

Sympathetic Vascular Transduction Across the Menopause Transition: Contributing Mechanisms

The investigators aim to assess the interactions between the sympathetic nervous system and the vasculature in women across the menopause transition to better understand why aging women have a higher risk of cardiovascular disease.

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Key information

Conditions

Menopause

Age range

18 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Early Phase 1

Primary location

University of Missouri

Columbia, Missouri, 65211, United States

Location status: Recruiting

Location contact

Jacqueline Limberg

CONTACT

[email protected]

573-882-2544

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Assigned female at birth
  • 18-70 years of age
  • Body mass index (BMI) <30 kg/m2

Exclusion criteria

  • Assigned male at birth
  • Pregnancy, breastfeeding
  • Body mass index ≥30 kg/m2
  • Oral hormonal contraception in last 6 months, history of hormone replacement therapy, oophorectomy
  • Current smoking/nicotine use
  • Increased risk of bleeding, pro-coagulant disorders, clotting disorders, anticoagulation therapy
  • Nerve/neurologic disease
  • Cardiovascular, hepatic, renal, respiratory disease
  • Blood pressure ≥140/90 mmHg
  • Diabetes, Polycystic ovarian syndrome
  • Communication barriers
  • Prescription medications

Treatment and study plan

Propranolol Hydrochloride

Drug

Examine how IV propranolol impacts sympathetic transduction

Phentolamine Injection

Drug

Examine how IV phentolamine impacts sympathetic transduction

Primary outcomes

  1. Sympathetic transduction

    Time frame: 1 day (single study visit)

    Assessing the relative change in blood flow (Doppler ultrasound) following an increase in sympathetic nerve activity.

Secondary outcomes

  1. Blood flow

    Time frame: 1 day (single study visit)

    Measuring femoral artery blood flow using Doppler ultrasound.

  2. Muscle sympathetic nerve activity

    Time frame: 1 day (single study visit)

    Measuring the sympathetic nerve activity of the fibular nerve using a microelectrode .

Study contacts

Contact information is provided by the study sponsor or research team.

Jacqueline Limberg, PhD

CONTACT

[email protected]

573-882-2420

Sponsors and collaborators

Lead sponsor

University of Missouri-Columbia

Other

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Jan 22, 2025
Registry last updated
Sep 15, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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