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Completed

NCT Number: NCT01043419

Sympathetic Neural Outflow During Xenon Anesthesia in Humans

The purpose of this study is to test the hypothesis that sympathetic neural outflow to muscles as well as a sympathetic baroreflexes are not altered during xenon anesthesia in Healthy Volunteers.

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Key information

Conditions

Sympathetic Nervous System

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Department of Anesthesiology; University Hospital of Duesseldorf; Moorenstrasse 5

Düsseldorf, 40225, Germany

About this study

Objectives for this study :

  • Main Objective : Influence of Xenon anesthesia on Sympathetic Nervous Activity
  • Secondary Objectives : Security under LENOXe™ (xénon 100 % v/v) anesthesia

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteers > 18 years and < 65 years of age
  • ASA physical status I
  • Legal competence
  • for whom the consent form has been signed

Exclusion criteria

  • Healthy volunteers < 18 years and > 65 years of age
  • Pregnancy, lactation period or missing secure anticonvulsive therapy
  • Missing legal competence
  • Participation in other clinical trials
  • Contraindications as mentioned on §4.3 of the SPCs of LENOXe™ (xénon 100 % v/v)
  • Any medication especially of Sildenafil (Viagra®) or other potency remedy
  • Existing relationship of dependency to the sponsor or the investigator

Treatment and study plan

Xenon

Drug

Inhalational gas; dose allowed max.70 Vol.% in 30 % oxygen; the duration of the treatment will be to 30 minutes

Primary outcomes

  1. Muscle Sympathetic Activity (MSA)and Baroreflex reagibility under Xenon Anesthesia in comparison to awake

    Time frame: 30 minutes

Secondary outcomes

  1. Arterial blood pressure, Heart frequency, Arterial O2 and CO2 Saturation,Skin conductance,Concentration of plasma catecholamines, Angiotensin & Renin under Xenon Anesthesia in comparison to awake

    Time frame: In continuous during 30 minutes

Sponsors and collaborators

Lead sponsor

Air Liquide Santé International

Industry

Registry information

Important dates

Study start
2010
Primary completion
2010
Study completion
2010
First posted
Jan 6, 2010
Registry last updated
Sep 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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