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OpenTrials
Completed

NCT Number: NCT06338761

Switching to E-cigarette After PCI

Despite the increasing popularity of electronic cigarettes (E-cigarettes), the prognostic impact of switching to E-cigarettes in smokers with coronary artery disease (CAD) who underwent percutaneous coronary intervention (PCI) remains uncertain.

Completed

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Key information

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Samsung Medical Center

Seoul, South Korea

About this study

Recently, several studies have reported that, although lower than combustible cigarette users, E-cigarette users had a significantly higher risk of future myocardial infarction (MI) or cardiovascular disease compared with non-smokers or quitters. However, because all previous studies has focused on the general healthy population, these results cannot be extrapolated for patients who already proven atherosclerotic cardiovascular disease (ASCVD), such as undergoing percutaneous coronary intervention (PCI) for coronary artery disease (CAD). Although Busch et al. previously reported that a significant minority of patients are using E-cigarettes post-acute coronary syndrome smokers, a paucity of data exists regarding the impact of such transitions on clinical outcomes in current smoker patients with CAD who have undergone PCI. In light of these considerations, the current study sought to address this gap in knowledge by evaluating the prognostic implications of smoking habit changes, including E-cigarette use, among CAD patients with current smoking status following PCI.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients who underwent health screening 3 years before and after the PCI

Exclusion criteria

  • history of cancer
  • history of ischemic stroke
  • died within the first 3 months of follow-up from the index date
  • Newly developed acute MI or received additional PCI or CABG from the index PCI date to the study index date

Treatment and study plan

smoking cessation

Behavioral

Stop smoking

Switching to E-cigarette

Behavioral

Switching to E-cigarette

Primary outcomes

  1. MACE

    Time frame: 5 years after PCI

    Major adverse cardiac event

Secondary outcomes

  1. Cardiovascular death

    Time frame: 5 years after PCI

    death from cardiovascular cause

  2. All-cause death

    Time frame: 5 years after PCI

    death from any cause

  3. Spontaneous myocardial infarction

    Time frame: 5 years after PCI

    MI with hospitalization

  4. Repeat revascularization

    Time frame: 5 years after PCI

    additional PCI or CABG

Sponsors and collaborators

Lead sponsor

Samsung Medical Center

Other

Registry information

Official study title

Prognostic Impact of Switching to E-Cigarette Use in Smokers With Coronary Artery Disease Following Percutaneous Coronary Intervention: A Nationwide Cohort Study

Acronym: E-cig-PCI

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Apr 1, 2024
Registry last updated
May 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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