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NCT Number: NCT02282748

Swiss Longitudinal Cohort

The planned research project is a prospective population-based cohort study, similar to the well-known Framingham study in the United States. So far, there is no similar research project in Switzerland.

It is planned to examine of three Swiss municipalities. Recruitment in a first Swiss municipality (Lostallo/Cama GR) started 2014 and ended in 2019. Overall, 496 participants were recruited in this municipality. The five-year follow-up in this municipality started in 2019. It is planned to start recruitment in a second Swiss municipality (Uznach SG) in 2020.

The examinations embrace a broad spectrum of measurements (for details the investigators refer to the published study protocol).

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Key information

Conditions

Cardiovascular Risk Factors

Age range

6 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Linth Hospital, Uznach, Canton of St. Gallen, Switzerland

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Resident of Cama GR, Lostallo GR, or Uznach SG
  • Age ≥6 years (no upper age limit), for voluntary blood sample ≥18 years
  • Willing to participate in long-term study
  • Written informed consent (in participants ≥6 years and <18 years signed by parents)

Exclusion criteria

  • No exclusion criteria

Treatment and study plan

No intervention

Other

Primary outcomes

  1. Mortality

    Time frame: 10 years

Secondary outcomes

  1. Cardiovascular events

    Time frame: 10 years

    Cardiovascular events (i.e. stroke, myocardial infarction) will be assessed using questionnaires and case records.

  2. Heart function

    Time frame: 10 years

    Heart function will be assessed using questionnaires for symptoms, clinical examination and measurement of electromechanical activation time.

  3. Cognitive function

    Time frame: 10 years

    Cognitive function will be assessed using validated instruments.

  4. Kidney function

    Time frame: 10 years

    Kidney function will be assessed using laboratory measurements.

  5. Autonomy

    Time frame: 10 years

    Autonomy wil be assessed using validated instruments.

  6. Nursing home admission

    Time frame: 10 years

    Nursing home admissions will be assessed using standardized questions.

Other outcomes

  1. Changes in cardiovascular risk factors

    Time frame: 10 years

    Cardiovascular risk factors will be assessed using validated measurements.

Study contacts

Contact information is provided by the study sponsor or research team.

Andreas W Schoenenberger, MD

CONTACT

[email protected]

Paul Erne, MD

CONTACT

[email protected]

Sponsors and collaborators

Lead sponsor

Hypertension Excellence Centre Lucerne

Other

Registry information

Important dates

Study start
2014
Primary completion
2024
Study completion
2034
First posted
Nov 4, 2014
Registry last updated
Feb 18, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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