SWedish Intensive Care Biobank

The goal of this observational study is to understand the genetic and molecular risk factors for developing critical illness in adult intensive care unit (ICU) patients in Sweden. The main questions it aims to answer are:

Which genetic variants are associated with increased risk of critical illness from conditions such as infections, sepsis, and organ failure?

Can circulating proteins and metabolites mediate the effect of genetic risk factors on the severity of illness?

Participants will:

Provide blood samples at ICU admission and again 3-6 months after discharge Consent to genetic analysis and data linkage with national health registries

Have their ICU treatment and outcomes followed using registry and clinical data

This study aims to build a national infrastructure for rapid sample collection and analysis that can also support research in future pandemics.

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Key information

Conditions

Any Condition Underlying Critical Illness Acute Kidney Injury Acute Lung Injury Cardiovascular Diseases Critical Illness Disease Attributes Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Heart Diseases Heart Failure Infections Inflammation Kidney Diseases Lung Diseases Lung Injury Male Urogenital Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Renal Insufficiency Respiratory Tract Diseases Sepsis Shock Systemic Inflammatory Response Syndrome Urogenital Diseases Urologic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults admitted to intensive care in Sweden

Exclusion criteria

Non adults
Not admitted to intensive care

Treatment and study plan

Primary outcomes

30 day mortality

Time frame: 30 days

Death of any cause within 30 days of ICU admission
ICU admission

Time frame: 30 days

ICU admission for any specific cause

Study contacts

Contact information is provided by the study sponsor or research team.

Michael Marks-Hultström, MD PhD

CONTACT

[email protected]

0186110000

Sponsors and collaborators

Lead sponsor

Uppsala University

Other

Registry information

Official study title

Hereditary Influence on Risk Factors for Severe Illness in a Swedish Intensive Care Biobank

Acronym: SWIC-B

Important dates

Study start: 2027
Primary completion: 2035
Study completion: 2035
First posted: May 13, 2026
Registry last updated: May 13, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed