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Recruiting

NCT Number: NCT05465538

SV2A in Older Adults

The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using [11C]UCB-J PET imaging.

Recruiting

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Key information

Conditions

Cannabis Use

Age range

50 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

Conneticut Mental Health Center

New Haven, Connecticut, 06519, United States

Location status: Recruiting

Location contact

Angerlyk Frytz, MD

CONTACT

[email protected]

203-974-7822

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Able to provide informed consent
  • Male or female, aged ≥50 years
  • No history of significant medical or neurological disease
  • BMI ≤ 50
  • If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans

Exclusion criteria

  • Women with a positive pregnancy test or women who are lactating
  • Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;
  • History of a bleeding disorder or are currently taking anticoagulants
  • Subjects who have donated blood within 8 weeks of the present study

Treatment and study plan

[11C]UCB-J PET

Drug

Single PET scan using the radioligand [11C]UCB-J

Primary outcomes

  1. Hippocampal synaptic density

    Time frame: 1 month

    Measure of synaptic density in the hippocampus

Study contacts

Contact information is provided by the study sponsor or research team.

Angerlyk Frytz, MD

CONTACT

[email protected]

203-974-7822

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Effect of Cannabis Use on Synaptic Density in Older Adults

Important dates

Study start
2022
Primary completion
2026
Study completion
2027
First posted
Jul 19, 2022
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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