Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Hypoxic Pulmonary Vasoconstriction

It has been shown, that subjects susceptible to high altitude pulmonary edema (HAPE)are characterized by an abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia. This abnormal rise of pulmonary artery pressure has also been observed in about 10 % of otherwise healthy subjects without prior altitude exposure. The aim of the study is to investigate the susceptibility to HAPE in unacclimatized subjects with abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia after rapid ascent to high altitude (4559 m).

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Key information

Conditions

High Altitude Pulmonary Edema Altitude Sickness Hypoxia Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Sports Medicine, University Hospital

Heidelberg, 69120, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

abnormal increase of pulmonary artery pressure at rest in hypoxia and during exercise in normoxia
ability to climb Margherita Hut

Exclusion criteria

Birth at or above 1500 m altitude
any cardiovascular or pulmonary disease
Infection disease
Intake of drugs, in particular Acetazolamide, Nifedipine, corticosteroids or PDE-5-inhibitors.
Pregnancy

Treatment and study plan

Altitude Exposure:

Other

rapid ascent to Margherita Hut (4559 m) within 24 h

Primary outcomes

Frequency of HAPE after rapid ascent to 4559 m

Time frame: during the 48 h stay at altitude

Secondary outcomes

Time course of pulmonary artery pressure

Time frame: during the 48 h stay at altitude
Assessment of right ventricular function by echocardiography

Time frame: during the 48 h stay at altitude

Sponsors and collaborators

Lead sponsor

Heidelberg University

Other

Registry information

Official study title

Susceptibility to High Altitude Pulmonary Edema in Subjects With Increased Pulmonary Artery Pressure During Exercise in Normoxia and at Rest in Hypoxia

Important dates

Study start: 2007
Primary completion: 2010
Study completion: 2011
First posted: Nov 16, 2007
Registry last updated: Sep 6, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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