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OpenTrials
Completed

NCT Number: NCT05473000

Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise

Ground level ozone (O3) is a common airborne pollutant that is well recognized to cause negative respiratory symptoms and impair pulmonary function. The proposed study aims to have participants perform submaximal and maximal cycling exercise protocols exposed to both O3 and room air in a crossover design to evaluate how ventilatory patterns, pulmonary function, development of symptoms, and cycling performance are impacted by O3 exposure. Additionally, the investigators look to compare responses between O3 at rest and during exercise to predict which subjects may be most susceptible to adverse response, as considerable interindividual variability exists.

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Key information

Conditions

Ozone Exposure During Rest and Exercise Behavior Disease Attributes Disease Susceptibility Motor Activity Pathologic Processes Pathological Conditions, Signs and Symptoms Respiration Disorders Respiratory Aspiration Respiratory Tract Diseases

Age range

18 year–50 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

University of British Columbia

Vancouver, British Columbia, V6T 1Z1, Canada

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy males between the age of 18 and 50
  • Currently training and/or competing in endurance sport
  • VO2max >60 ml/kg/min
  • Able to communicate sufficiently using the English language

Exclusion criteria

  • History of smoking
  • Upper respiratory tract infection within the last 4 weeks
  • Presence of any chronic respiratory disease

Treatment and study plan

Exercise

Behavioral

Submaximal and maximal exercise

Ozone

Other

Delivery of ozone air pollution at 170ppb

Room air

Other

Delivery of room air

Primary outcomes

  1. Time-to-exhaustion on Maximal Cycling Bout

    Time frame: From the beginning of the maximal constant work-rate cycling bout until volitional exhaustion occurs (roughly 1-5 minutes)

    Measurement of time (in seconds) to volitional exhaustion on a constant work-rate cycling trial at 110% of previously determined maximal power output.

Sponsors and collaborators

Lead sponsor

University of British Columbia

Other

Collaborators

  • Natural Sciences and Engineering Research Council, Canada

Registry information

Official study title

Investigating Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise Based on Resting Ozone Exposure

Important dates

Study start
2022
Primary completion
2023
Study completion
2024
First posted
Jul 25, 2022
Registry last updated
Apr 13, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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