Survival TRial Using CytoKines in COVID-19 (STRUCK Trial)

Inclusion criteria

• Positive result in the quantitative real-time PCR (qPCR) test for SARS-CoV-2 in the respiratory tract;
• Pneumonia confirmed by chest imaging and

• Respiratory rate ≥ 24 IRPM (for adults) or
• O2 saturation <93% or
• No improvement in O2 saturation, despite oxygen supply or
• Arterial hypotension; or
• Changes in capillary filling time; or
• Changes in the level of consciousness; or
• Oliguria;

IMPORTANT: The presence of increased respiratory rate or desaturation (items "a" and "b") are criteria for hospital admission. Items "c" to "g" are considered criteria for ICU admission

Following the recommendations of The São Paulo State Health Secretariat, resolution SS-28 of 03-Mar-2020, prepared by the Hospital das Clínicas of Medical School-USP.

Exclusion criteria

• Age <18 years;
• Refuse to sign the Informed Consent Form;
• Patient's decision that their involvement is not in their interest;
• Severe known liver disease (eg cirrhosis, with aminotransferase levels> 5 times the reference value limit);
• Pregnancy or breastfeeding period;
• Severe bacterial infection;
• Severe diarrhea;
• Diverticulitis or intestinal perforation;
• Infection known as HIV;
• Presence of one of the following uncontrolled or unstable cardiovascular diseases: stroke, ECG confirmed acute ischemia or myocardial infarction and / or clinically significant dysrhythmia; • Known history of gastrointestinal bleeding, uncontrolled peptic ulcer or uncontrolled duodenal ulcer;
• Known history of hemophilia or other bleeding disorders;
• History of organ transplantation, congenital immunodeficiency;