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OpenTrials
Completed

NCT Number: NCT05175963

Surveillance Among Healthcare Workers for SARS-Coronavirus-2 Infection

This study aims to investigate the epidemiology of SARS-CoV-2 infection among: i) HCW who triage patients with suspected SARS-CoV-2 infection and provide care to COVID-19 patients; and ii) laboratory personnel who test clinical samples for SARS-CoV-2 infection. After the second wave of the pandemic enrolment will be widen to any person working at the study hospitals.

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Key information

Conditions

COVID-19 Coronaviridae Infections Coronavirus Infections Infections Lung Diseases Nidovirales Infections Pneumonia Pneumonia, Viral RNA Virus Infections Respiratory Tract Diseases Respiratory Tract Infections SARS-CoV2 Infection Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Chris Hani Baragwanath Academic Hospital

Johannesburg, GP, 2192, South Africa

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • HCWs of any staff category at the study hospitals.

Exclusion criteria

  • None

Treatment and study plan

Primary outcomes

  1. To determine the prevalence of symptomatic and asymptomatic SARS-CoV-2 infections among HCW.

    Time frame: 2020

    To determine the prevalence of symptomatic and asymptomatic PCR-confirmed SARS-CoV-2 infections among HCW using a systematic sampling strategy, coupled with investigation when clinically indicated.

Secondary outcomes

  1. To define the duration of viral "shedding".

    Time frame: 2020

    To define the duration of "shedding" (using molecular based PCR methods) of SARS-CoV-2 in HCW who are identified to be infected with the virus.

  2. To do sero-epidemiology assessment.

    Time frame: 2022

    To undertake serial sero-epidemiology studies on prevalence of SARS-CoV-2 antibodies among HCW.

  3. To analyse immune responses to SARS-CoV-2 infection.

    Time frame: 2022

    To analyse immune responses (humoral and cell mediated) to SARS-CoV-2 infection.

  4. To investigate the possibility of viral re-infection in this population during the study period.

    Time frame: 2022

    To investigate the possibility of viral re-infection during the different pandemic waves in this population during the study period.

  5. To establish if common cold coronaviruses (CCCV) immunity confers protection against SARS-CoV-2 infection or disease severity

    Time frame: 2022

    To establish if common cold coronaviruses (CCCV) immunity confers protection against SARS-CoV-2 infection or disease severity by measuring antibodies to CCCV.

  6. To evaluate COVID-19 vaccine effectiveness (VE) amongst HCWs, against any PCR-confirmed SARS-CoV-2 infection.

    Time frame: 2022

    To evaluate COVID-19 vaccine effectiveness (VE) amongst HCWs, against any PCR-confirmed SARS-CoV-2 infection.

  7. To measure humoral and cell mediated immune responses to COVID-19 vaccines stratified by previous SARS-CoV-2 infection.

    Time frame: 2022

    To measure humoral and cell mediated immune responses to COVID-19 vaccines stratified by previous SARS-CoV-2 infection.

Sponsors and collaborators

Lead sponsor

Farzanah Laher

Other

Registry information

Important dates

Study start
2020
Primary completion
2022
Study completion
2022
First posted
Jan 4, 2022
Registry last updated
May 28, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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