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Completed

NCT Number: NCT06778915

Surgical Strategy for Head and Neck Adenoid Cystic Cancer

To investigate the relationship between surgical margins and outcomes across different tumor stages, in order to provide evidence and guidance for refining stage-specific surgical approaches.

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Key information

Conditions

Adenoid Cystic Carcinoma Adenocarcinoma Carcinoma Carcinoma, Adenoid Cystic Neoplasms Neoplasms by Histologic Type Neoplasms, Glandular and Epithelial

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

Adenoid cystic carcinoma of the head and neck (HNACC) presents unique surgical challenges due to its propensity for perineural spread and proximity to critical craniofacial structures. While surgical resection remains the cornerstone of treatment, determining the optimal extent of resection to balance oncologic control and functional preservation requires further investigation. The investigator aimed to investigate the relationship between surgical margins and outcomes across different tumor stages, in order to provide evidence and guidance for refining stage-specific surgical approaches.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients who underwent surgical resection with curative intent and PORT.

Exclusion criteria

  • underwent only biopsy, presented with distant metastases or second primary malignancies at initial diagnosis, had incomplete clinical or histopathologic data, or had histologic evidence of high-grade transformation.

Treatment and study plan

Surgery

Procedure

surgery

Primary outcomes

  1. Local control

    Time frame: 5 year

    defined as the absence of tumor persistence, recurrence, or progression at the primary tumor site following the completion of treatment, assessed by clinical examination and imaging at designated follow-up intervals.

Secondary outcomes

  1. Locoregional Recurrence-Free Survival (LRRFS)

    Time frame: 5 year

    time from treatment initiation to either locoregional recurrence or death from any cause

  2. Overall Survival (OS)

    Time frame: 5 year

    time from treatment initiation to death from any cause

  3. Distant Metastasis-Free Survival (DMFS)

    Time frame: 5 year

    time from treatment initiation to either distant metastasis or death from any cause

Sponsors and collaborators

Lead sponsor

Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University

Other

Registry information

Official study title

Refining Surgical Strategies Based on Tumor Staging in Head and Neck Adenoid Cystic Carcinoma: Evidence from a Retrospective Cohort Study

Important dates

Study start
2016
Primary completion
2022
Study completion
2024
First posted
Jan 16, 2025
Registry last updated
Jan 16, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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