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Completed

NCT Number: NCT01470586

Surgical Resection Lowers Oxidative Stress Markers in Patients With Colorectal Cancer

Study of Oxidative stress Markers (F2 Isoprostanes for lipid peroxidation, Carbonyl groups for protein peroxidation, 3 Nitrotyrosine for damage by nitrogens, and 8-Hydroxyguanosine for RNA peroxidation)in patients with colorectal cancer undergo surgical treatment (preoperatively during the intervention and postoperatively) and controls.

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Key information

Conditions

Colorectal Cancer Colon Rectal Resection Colonic Diseases Colorectal Neoplasms Digestive System Diseases Digestive System Neoplasms Gastrointestinal Diseases Gastrointestinal Neoplasms Intestinal Diseases Intestinal Neoplasms Neoplasms Neoplasms by Site Oxidative Stress Rectal Diseases

Age range

25 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

G. Hatzikosta General Hospital

Ioannina, Epirus, 45001, Greece

About this study

Study of the impact of surgery on Lipid peroxidation, Protein peroxidation, damage by nitrogens, and RNA peroxidation, in patients undergo surgical resection for colorectal cancer and compared with controls, and validation of the responsiveness of oxidative stress markers on surgery

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with colorectal cancer
  • Controls

Exclusion criteria

  • ASA>3
  • Metastatic Disease
  • Acute bowel obstruction
  • Acute bowel perforation
  • BMI<30
  • Chronic Systemic or Autoimmune Diseases
  • Smokers
  • Alcohol consumers

Treatment and study plan

Surgery for colorectal cancer

Procedure

Surgical resection of colorectal cancer

Other names: Open or Laparoscopic resection for colorectal cancer, Low anterior resection, Sigmoidectomy, Left colectomy, Trasverse colectomy, Right colectomy

Primary outcomes

  1. Comparison of Oxidative stress markers in patients with colorectal cancer and controls

    Time frame: up to 2 years

    Oxidative stress markers variation (8-PGF2α, Protein Carboyls, 3-Nitrotyrosine, 8-OHG) during and after surgery for colorectal cancer, and compare with controls

Secondary outcomes

  1. Validation of oxidative stress markers in patients with colorectal cancer undergo surgical resection

    Time frame: up to 2 years

    Validation of the responsiveness of markers of oxidative stress 8-PGF2α, Protein Carboyls, 3-Nitrotyrosine, 8-OHG)on surgery

Sponsors and collaborators

Lead sponsor

G. Hatzikosta General Hospital

Other

Collaborators

  • University of Ioannina

Registry information

Important dates

Study start
2009
Primary completion
2010
Study completion
2011
First posted
Nov 11, 2011
Registry last updated
Nov 11, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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