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Completed

NCT Number: NCT07026825

Surgical Resection Enhances Survival in Gastric-type Endocervical Adenocarcinoma: A SEER-Based Study

This retrospective cohort study analyzes the effect of surgical resection on survival outcomes in patients with gastric-type endocervical adenocarcinoma (GAS), using data from the SEER database (2000-2021). Propensity score matching and multivariable Cox regression were used to compare overall survival (OS) and tumor-specific survival (TSS) between patients who underwent surgery and those who did not. The study aims to determine whether primary tumor resection is associated with improved survival across tumor sizes and stages.

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Key information

Conditions

Gastric-type Endocervical Adenocarcinoma

Age range

18 year and older

Sex eligibility

Female

Study type

Observational

About this study

The study utilized de-identified data from the SEER program encompassing women aged ≥18 with histologically confirmed gastric-type endocervical adenocarcinoma between 2000 and 2021. The primary endpoints were overall survival and tumor-specific survival. Statistical analyses included multivariable Cox regression, propensity score matching (2:1), and inverse probability of treatment weighting (IPTW). Subgroup analyses were performed based on FIGO stage and tumor size (>4 cm). A total of 308 eligible cases were included. No patient interaction or clinical intervention occurred.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Histologically confirmed gastric-type endocervical adenocarcinoma Cervix as the first primary site Diagnosis between 2000 and 2021

Exclusion criteria

Incomplete survival or treatment data Diagnosis not confirmed microscopically

Treatment and study plan

Primary outcomes

  1. Outcome

    Time frame: Time from diagnosis to death from any cause Up to 22 years (2000-2022)

    Overall Survival (OS)

Sponsors and collaborators

Lead sponsor

Cancer Hospital Chinese Academy of Medical Science, Shenzhen Center

Other

Registry information

Official study title

Surgical Resection Improves Survival in Gastric-type Endocervical Adenocarcinoma: A SEER-Based Propensity-Matched Cohort Study

Acronym: SURGE

Important dates

Study start
2000
Primary completion
2021
Study completion
2022
First posted
Jun 18, 2025
Registry last updated
Jun 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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