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OpenTrials
Completed

NCT Number: NCT00562822

Surgery Versus No Surgery for Osteoarthritis (OA) of the Knee

The purpose of this study is to discover whether arthroscopic surgery is helpful in controlling the symptoms of osteoarthritis of the knee.

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Key information

Conditions

Osteoarthritis of the Knee Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Primary location

London Health Sciences Centre - University Hospital

London, Ontario, N6A 5A5, Canada

About this study

Although arthroscopic surgery has been widely used for osteoarthritis of the knee, scientific evidence to support its efficacy is lacking. This study will compare optimized physical and medical therapy alone with arthroscopic treatment in addition to optimized physical and medical therapy.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Idiopathic or secondary osteoarthritis of the knee with Grade II to IV radiographic severity as defined by the modified Kellgren and Lawrence classification

Exclusion criteria

  • Patients with inflammatory or post-infectious arthritis
  • Those who had undergone previous arthroscopic treatment for knee osteoarthritis
  • Those with isolate Grade III to IV medical compartment osteoarthritis with greater than 5 degrees of varus deformity.

Treatment and study plan

Arthroscopic surgery

Procedure

Arthroscopic surgery to treat unresolved symptoms of osteoarthritis of the knee

Physical and medical therapy

Other

Treatment with physical and medical therapy alone

Primary outcomes

  1. Function, pain and quality of life based on the WOMAC (Western Ontario and McMaster Universities Osteoarthritis Index) scores

    Time frame: 2 years

Secondary outcomes

  1. Health utility using the Standard Gamble Technique

    Time frame: 24 months

Sponsors and collaborators

Lead sponsor

University of Western Ontario, Canada

Other

Collaborators

  • Canadian Institutes of Health Research (CIHR)

Registry information

Official study title

Arthroscopic vs. Non-surgical Treatment of Osteoarthritis of the Knee

Acronym: MRC Knee

Important dates

Study start
1999
Primary completion
2007
Study completion
2007
First posted
Nov 22, 2007
Registry last updated
May 22, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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