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OpenTrials
Completed

NCT Number: NCT07149805

Surgery Benefits Takayasu Arteritis With Stenosis in the Descending Aorta

The long-term prognosis and optimal management for Takayasu arteritis(TA) patients with severe stenosis of the descending thoracic and abdominal aorta remain undefined. We want to compare the clinical outcomes of surgical intervention and medical management.

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Key information

Conditions

Takayasu Arteritis Aortic Arch Syndromes Aortic Diseases Arteritis Cardiovascular Diseases Skin Diseases Skin Diseases, Vascular Skin and Connective Tissue Diseases Vascular Diseases Vasculitis

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • fulfilling the 1990 American College of Rheumatology criteria for the diagnosis of TA;
  • having at least one site with severe narrowing in the descending thoracic and abdominal aorta;
  • having symptoms caused by TA-related stenosis, such as uncontrolled hypertension, heart failure, renal ischemia, dizziness, visual disturbances, and claudication

Exclusion criteria

Patients with arterial stenosis due to other reasons (such as typical atherosclerosis, congenital coarctation of the aorta, and anatomical abnormality) were excluded

Treatment and study plan

open surgery or interventional treatment

Procedure

open surgery or interventional treatment

Primary outcomes

  1. all-cause mortality rate

    Time frame: Patients underwent follow-up from discharge until study termination (3 years to 11 years) or death, whichever came first

  2. all-cause mortality rate

    Time frame: Patients underwent follow-up from discharge (3 years to 11 years) until study termination or death, whichever came first

Sponsors and collaborators

Lead sponsor

Peking Union Medical College Hospital

Other

Registry information

Official study title

Surgery Improves Survival Rate in Patients With Takayasu Arteritis: a Retrospective Observational Study

Important dates

Study start
2004
Primary completion
2025
Study completion
2025
First posted
Sep 2, 2025
Registry last updated
Sep 2, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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