Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07316166

Suprainguinal Fascia Iliaca Block With vs Without Dexmedetomidine

The investigators are evaluating postoperative outcomes in patients undergoing hip replacement surgery performed with either spinal or general anesthesia, who also receive a suprainguinal fascia iliaca block using either perineural ropivacaine alone or ropivacaine combined with dexmedetomidine.

Recruiting

Interested in participating?

Request Info

Key information

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

About this study

Patients undergoing hip replacement surgery often receive a single-shot suprainguinal fascia iliaca block as a part of the primary anesthetic and multimodal postoperative analgesic strategy. However, the analgesic effect of a single-shot block typically diminishes after several hours and may be inconsistent beyond 24 hours. Adding dexmedetomidine, an alpha-2 agonist, to the local anesthetic has been shown to prolong block duration and reduce postoperative opioid requirements. Investigating its use in suprainguinal fascia iliaca blocks for total hip arthroplasty may clarify its clinical effectiveness. The investigators hypothesize that patients receiving ropivacaine with dexmedetomidine will have a significantly longer time to first analgesic request compared to those receiving ropivacaine alone.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients undergoing elective total hip arthroplasty
  • 18-80 years old
  • ASA 1-3 classifications

Exclusion criteria

  • ASA classification of 4 or greater
  • Infection at the site of nerve blockade
  • Coagulopathy
  • Known allergy to study medications
  • Chronic opioid consumption (>3 months)
  • Currently using lidocaine patches
  • Pre-existing neuropathy
  • A history of CVA
  • High grade atrioventricular block (cardiac conduction system impairment)
  • Organ dysfunction (cardiac failure, respiratory failure, end stage renal disease, hepatic dysfunction, hypoalbuminemia)
  • Morbid obesity (≥40 kg/m2)
  • Prior surgery in supra and/or infrainguinal region
  • Non-English-speaking participants

Treatment and study plan

Dexmedetomidine

Drug

Participants in the experimental arm receive a preoperative suprainguinal fascia iliaca block consisting of 30 mL of 0.25% ropivacaine combined with perineural dexmedetomidine at a dose of 1 mcg/kg.

Ropivacaine

Drug

In the experimental arm, ropivacaine (30 mL of 0.25%) is administered with dexmedetomidine.

In the active comparator arm, ropivacaine (30 mL of 0.25%) is administered alone without any dexmedetomidine medication.

Primary outcomes

  1. Time of administration of first analgesic after the surgery

    Time frame: Time to first analgesic request, defined as the interval (in minutes) from block administration to the first request for rescue analgesia, assessed for up to 24 hours.

Secondary outcomes

  1. Total opioid consumption (converted to morphine milligram equivalents)

    Time frame: From the start of surgery through 48 hours postoperatively

    Intraoperative period; PACU; and at 6, 12, 24, and 48 hours following surgery.

  2. Quality of Recovery

    Time frame: 24 hours

    The QoR-15 questionnaire has 15 questions that assess patient-reported quality of a patient's postoperative recovery using a 11-point numerical rating scale that leads to a minimum score of 0 (poor recovery) and a maximum score of 150 (excellent recovery).

  3. Pain Scores

    Time frame: Up to two hours [post anesthesia recovery unit], 6 hours, 12 hours, 24 hours and 48 hours after surgery

    Patients will be asked to rate their pain score on a 11-point scale (0 = no pain to 10 = excruciating pain).

Study contacts

Contact information is provided by the study sponsor or research team.

Vendhan Ramanujam, M.D.

CONTACT

[email protected]

401-444-5172

Sponsors and collaborators

Lead sponsor

Rhode Island Hospital

Other

Registry information

Official study title

Comparison of Suprainguinal Fascia Iliac Block With and Without Dexmedetomidine as an Adjunct to Ropivacaine for Postoperative Analgesia Following Hip Surgery: a Randomized, Double-blinded Study.

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Jan 5, 2026
Registry last updated
Mar 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.