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Completed

NCT Number: NCT03677492

Supplementing Intracytoplasmic Sperm Injection Handling Medium With Cytochalasin D ( ICSI-CD)

Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Cytochalasin D serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Cytochalasin D during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year–42 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Banon Assiut, Asyut, Egypt

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ICSI indicated participants

Exclusion criteria

-

Treatment and study plan

Medium Supplemented with Cytochalasin D

Other

A medium with in-house supplementation of Cytochalasin D to decrease oocyte degeneration after ICSI and improve the survival rate

Primary outcomes

  1. Oocyte survival rate

    Time frame: 6 days of culture

Secondary outcomes

  1. Fertilization rate

    Time frame: 6 days of culture

  2. Blastocyst formation rate

    Time frame: 6 days of culture

  3. Embryo utilization rate

    Time frame: 6 days of culture

  4. Clinical pregnancy rate

    Time frame: three months

  5. Implantation rate

    Time frame: 7 weeks

  6. Ongoing pregnancy rate

    Time frame: 12 weeks

Sponsors and collaborators

Lead sponsor

Ibn Sina Hospital

Other Gov

Registry information

Official study title

Cytochalasin D Supplementation to ICSI Handling Medium

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Sep 19, 2018
Registry last updated
May 7, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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