Superior Colliculus Activity in Parkinson Disease: a Potential Marker?

This project aims at better understanding the physiopathology of Parkinson's disease and the effect of the administration of the classical medical treatment. The main aim of this project is to evaluate the possibility of an early detection using a new original strategy. The investigators want to demonstrate the predictive value of the superior colliculus light responses as an early biomarker.

The investigators will perform functional magnetic resonance imagery (fMRI) to measure the BOLD light responses of the superior colliculus at different key stages of the normal medical follow up of Parkinson's patients by the neurologist (when diagnosed, when introducing the first treatment and when the treatment is stabilised).

Two groups of participants will be tested: a) a group of de novo patients, which have just been diagnosed and haven't started their treatment; b) a group of matching controls.

A first fMRI session (S1) will be performed to compare the light induced BOLD response of the superior colliculus between de novo patients and their matching controls. This session will evaluate a possible visual processing dysfunction in the superior colliculus of newly diagnosed patients.

Parkinson's patients will then start their treatment and a second session (S2) will be done on this group shortly after the introduction of the treatment to measure its acute effect. If the superior colliculus of those patients presents a sensory rebound, the investigators should observe a bigger light-induced BOLD response after the treatment compared to before the treatment.

A third session (S3) will be performed after the optimal adjustment of the treatment on motor symptoms which would be around six month after the start of the treatment. This adjustment is long and difficult, realized by the neurologist according to its effect on the motor symptoms. Those two last fMRI will allow the investigators to compare the effect of the introduction of the treatment on the motor symptoms, known to not improve correctly at this stage, and on non-motor symptoms (visual processing deficits in this project) from which no information are available to the investigators knowledge.

Inclusion criteria

• De novo parkinson's patients being just diagnosed (stage 1 according to the Hoehn and Yahr scale: first unilateral signs with no discomfort in everyday life) without a current dopaminergic treatment and who have not started their anti-parkinsonian treatment.
• Both Parkinson's patients and their age matching control must not present a major visual pathology (mainly in the retina) which may interfere with the visual task.
• Signed informed and free consent.
• Matching controls must not present a neurological or psychiatric troubles.
• For the matching controls: There are no contraindication on current treatments apart from those to treat other neurological disease than Parkinson's disease or psychiatric troubles.
• For Parkinson's patients: There are no contraindication on current treatments apart from those to treat neurological troubles including anti-parkinsonian treatment, or psychiatric troubles.
• As a precaution, the investigators will check that no MRI exam has been performed during the week preceding our fMRI.

Exclusion criteria

• Parkinson's patients with important tremor limiting the validity of the fMRI acquisition.
• Adult under supervision
• Incapacity to understand the consent explanations.
• Impossibility to participate to the whole experimental protocol.
• No affiliation to a health insurance.
• Consent not signed by a participant or refusal by the participant to participate to the experiment.
• Pregnancy or breast feeding woman.
• Administrative or justice freedom restricted participant.

Exclusion criteria

specific for MRI:

• Pacemaker, neurosensorial stimulator or implanted defibrillator.
• Presence of ocular or cerebral ferromagnetic material.
• Respiratory disease (i.e. asthma), cardio-vascular deficits, claustrophobia