Suitability of DCE-MRI for Detection of Vascular Changes After VBT

This is a pilot study of DCE MR imaging to detect vascular changes in the vagina during and after radiotherapy n patients receiving adjuvant brachytherapyfor cervical or endometrial cancer.

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Key information

Conditions

Carcinoma of the Cervix, Carcinoma or Carcinosarcoma of the Uterus Carcinoma Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Genital Neoplasms, Female Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Urogenital Diseases Urogenital Neoplasms Uterine Cervical Diseases Uterine Cervical Neoplasms Uterine Diseases Uterine Neoplasms

Age range

18 year and older

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Abramson Cancer Center of the University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Must be 18 years of age.
Must have histologically confirmed carcinoma of the cervix, carcinoma or carcinosarcoma of the uterus.
Subjects are receiving intracavitary brachytherapy.
ECOG performance status of 0-2.
Creatinine clearance 30.

Exclusion criteria

Subjects with an inability to tolerate MR imaging (i.e. claustrphobia)
Study subjects who have contraindication to MRI scanning such as but not limited to subjects with pacemakers, metal fragments in the eye or certain metallic implants.
Patients who do not speak or read English.

Treatment and study plan

Radiotherapy

Radiation

Primary outcomes

Number of Participants With Adverse Events

Time frame: 2 years

Sponsors and collaborators

Lead sponsor

Abramson Cancer Center at Penn Medicine

Other

Registry information

Official study title

A Pilot Study to Assess the Suitability of DCE-MRI for Detection of Vascular Changes After Vaginal Brachytherapy

Important dates

Study start: 2013
Primary completion: 2016
Study completion: 2016
First posted: Nov 25, 2013
Registry last updated: Nov 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed