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Completed

NCT Number: NCT07145840

Suicidal Behavior Among Schizophrenic Patients

This study aimed to; -

1. Study suicidal behavior among sample of schizophrenic patients. 2. Study relation between schizophrenic symptoms and suicidal behavior. 3. Study the relation of mood symptoms in schizophrenic patients and suicidal behavior.

Completed

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Key information

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Tanta University

Tanta, El-Gharbia, 31527, Egypt

About this study

Suicide is a major public health concern. According to the World Health Organization (WHO), approximately one million people die by suicide each year worldwide. This statistic means that every 40 seconds, someone dies by suicide somewhere on the globe, with many more people making non-lethal suicide attempts. It has been suggested that the number of individuals who attempt suicide without causing death is about 10-15 times the number of those who die by suicide.

Schizophrenia is a severe psychiatric disorder characterized by cognitive impairment and behavioral dysfunction. Patients with schizophrenia are at an elevated risk of self-harm, suicide, and all-cause mortality, which results in a reduction of life expectancy of up to 20 years compared with the general population.

Suicide risk in schizophrenia is notably high, and early detection depends on recognizing and evaluating clinical manifestations of depression, despair, and hopelessness, as well as the nature and severity of the psychotic experience, particularly in recently diagnosed patients with higher cognitive function and educational backgrounds.

There is a lack of studies on suicidal behaviors in schizophrenic patients in Arab countries. A study on overall suicidality in Arab countries reported a lifetime suicide attempt rate of 0.72%-6.3% and a suicide ideation rate of 2.09%-13.9%. More research is needed in this area due to the societal and economic costs of suicidal behavior in schizophrenic patients. This issue is a high priority for public health. Several trials have aimed to identify valid predictors of suicide risk. These predictors could not only help reduce the mortality associated with suicidality but also enable a more rational allocation of resources for treatment. Previous suicide attempts, depressive symptoms, hopelessness, and akathisia have been identified as reliable predictors of suicidal behavior.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age between 18 and 60.
  • Both females and males will be included.
  • All patients should meet the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) criteria for schizophrenia.

Exclusion criteria

  • Any neurological disorder.
  • Past history of head trauma.
  • Medical or autoimmune disorders.
  • Other psychiatric disorders e. g. bipolar disorders, post-traumatic stress disorder (PTSD), obsessive compulsive disorder (OCD), and anxiety.
  • Pregnancy.

Treatment and study plan

Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)

Other

Psychiatric interview for diagnosis of schizophrenia by SCID 5 (American Psychiatric Association, 2015), The Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5) is a semi structured interview guide for making the major DSM-5 diagnoses using the chapter of schizophrenia spectrum

Primary outcomes

  1. Severity of Suicidal Ideation

    Time frame: Within 1 week prior to assessment

    Assessed using the Arabic version of the Beck Scale for Suicide Ideation (BSS), which includes 21 statement groups rated on a 3-point scale. The total score ranges from 0 to 38, with higher scores indicating more severe suicidal ideation.

Secondary outcomes

  1. Severity of Schizophrenia Symptoms

    Time frame: Within 7 days

    Measured using the Positive and Negative Syndrome Scale (PANSS), which assesses positive, negative, and general psychopathology symptoms. Higher scores reflect greater symptom severity.

  2. Severity of Depressive Symptoms

    Time frame: Within 7 days

    Measured using the Arabic version of the Hamilton Depression Rating Scale (HDRS-17). Total scores classify depression as mild, moderate, severe, or very severe.

Sponsors and collaborators

Lead sponsor

Tanta University

Other

Registry information

Official study title

A Study of Suicidal Behavior Among Schizophrenic Patients

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Aug 28, 2025
Registry last updated
Aug 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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