Sugar-replacement Sweeteners, and Blood Sugar Control

Several sugar-replacement sweeteners are currently on the market, including saccharine (ex. Sweet'N Low), aspartame (ex. Equal), and sucralose (ex. Splenda). The purpose of this study is to examine wether non caloric sweeteners affects how well the body works to control blood sugar. The study includes detailed blood sugar testing after drinking liquids that may contain sucralose. The investigators hypothesize that drinking liquids with sucralose will effect the amounts of specific appetite-affecting substances naturally produced by the body.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Obesity Body Weight Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

21 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Washington University School of Medicine

St Louis, Missouri, 63110, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

body mass index (BMI) over 30.
Homeostasis model assessment of insulin resistance (HOMA-IR) < or = 2.6

Exclusion criteria

smoking or smoked within last six months
pregnant or breastfeeding
have malabsorptive syndromes
intestinal inflammatory disease
diabetes
liver or kidney disease
fructose intolerance
consuming more than one can of diet beverage or one spoonful of non-nutritive sweeteners (e.g. sucralose, aspartame, or saccharine) a week.
taking any medication that might affect metabolism or taste.

Treatment and study plan

Water

Other

60 ml of water were drank 10 min before doing a OGTT

Sucralose

Other

60 ml of 2 millimolar sucralose were drank 10 min before doing a OGTT

Primary outcomes

The Effect of Sucralose on Insulin Concentration (Area Under the Curve; AUC)

Time frame: Baseline

we will measure plasma insulin concentrations during a 5-hour modified Oral Glucose Tolerance Test (mOGTT) administered 10 minutes after subjects consume sucralose in water or an equal volume of water without sucralose (control condition).Plasma insulin concentrations were measured at 20, 15, 10, 6, and 2 min before and at 10, 20, 30, 40, 60, 90, 120, 150,180, 240, and 300 min after ingesting 75g of glucose. All these data collected were used to create the AUC curve.

Sponsors and collaborators

Lead sponsor

Washington University School of Medicine

Other

Registry information

Official study title

Regulation of Incretin Release by Non-nutritive Sweeteners in Humans

Acronym: SIR

Important dates

Study start: 2010
Primary completion: 2012
Study completion: 2012
First posted: May 24, 2010
Registry last updated: Dec 22, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed