Sugammadex on Remifentanil Ce for Preventing Emergence Cough in Male

The primary purpose of this study is to investigate the optimal Ce of remifentanil for preventing emergence cough following extubation during general anesthesia in male patients who are reversed with sugammadex or neostigmine.

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Key information

Conditions

Gallbladder Diseases Biliary Tract Diseases Digestive System Diseases

Age range

65 year–80 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine

Suwon, Seoul, South Korea

About this study

Remifentanil is a potent ultrashort-acting opioid, with rapid onset and offset of drug effect. It allows rapid anesthetic emergence even after a prolonged infusion, and decreases the at-risk time during extubation. In addition, cough suppression of remifentanil enables smooth extubation with reduced complications. However, the infusion of remifentanil suppresses the emergence cough effectively in clinical practice, whereas it still delays the awakening from anesthesia, resulting in prolonged emergence time. Reduced Ce of remifentanil during emergence would decrease the adverse events that are associated with remifentanil infusion.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Laparoscopic cholecystectomy under general anesthesia

Exclusion criteria

BMI > 30 kg/m2, respiratory infection, uncontrolled hypertension

Treatment and study plan

Sugammadex Injectable Product

Drug

Sugammadex of 3 mg/kg is injected.

Neostigmine Injectable Product

Drug

Neostigmine of 50 ug/kg and Glycopyrrolate of 10 ug/kg are injected.

Primary outcomes

optimal Ce of remifentanil

Time frame: from the ene of surgery until endotracheal extubation

Using Dixon methods, evaluating of optimal Ce of remifentanil for preventing emergence cough following extubation during general anesthesia

Sponsors and collaborators

Lead sponsor

Ajou University School of Medicine

Other

Registry information

Official study title

Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine

Important dates

Study start: 2018
Primary completion: 2018
Study completion: 2018
First posted: Jul 11, 2018
Registry last updated: May 29, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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Completed