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OpenTrials
Completed

NCT Number: NCT01595815

Successful Pregnancy and Delivery After AOA

Artificial oocyte activation with strontium chloride or calcium ionophore improves fertilization, embryo quality, pregnancy and delivery rate in women who showed complete fertilization failure or low fertilization rates

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

20 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Maria Fertility Hospital

Seoul, 138-160, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Fertilization rate was less than 30% after conventional ICSI.
  • Fertilization rate was less than 50% after ICSI with calcium ionophore.
  • Repeated complete fertilization failure or low fertilization rates following ICSI in previous cycles

Exclusion criteria

  • Fertilization rate was more than 30% after conventional ICSI
  • Fertilization rate was more than 50% after ICSI with calcium ionophore.
  • Successful pregnancy and delivery after ICSI in previous cycles

Treatment and study plan

Calcium ionophore

Other

Oocytes were activated with calcium ionophore after ICSI

Strontium chloride (SrCl2)

Other

Oocytes were activated with strontium chloride after ICSI

Primary outcomes

  1. Fertilization rate

    Time frame: 18 hours

Secondary outcomes

  1. Embryo quality

    Time frame: 3 Days

  2. Pregnancy and Implantation rates

    Time frame: 2 months

  3. Assessment of Infant health care

    Time frame: birth and at 3, 6, 12, 24, 36, 60, and 72 months

    This assessment is according to the standard set by the National Health Insurance Service (NHIS) in Korea.

Sponsors and collaborators

Lead sponsor

Maria Fertility Hospital

Other

Registry information

Official study title

Successful Pregnancy and Delivery After AOA in Couples With Repeated Complete Fertilization Failure or Low Fertilization Rates

Important dates

Study start
2007
Primary completion
2011
Study completion
2014
First posted
May 10, 2012
Registry last updated
May 9, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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