Subthalamic Nucleus, Akinesia and Parkinson's Disease

Inclusion criteria

for patients who will be operated

• Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank)
• Age between 18 and 70;
• Motor complications in the form of fluctuations in motor state or dyskinesias induced by dopaminergic therapy, despite medical treatment optimum;
• Other medical conditions that are stable or do not interfere with the procedure proposed;
• Excellent responsiveness to levodopa (UPDRS motor score improvement greater than 50% in the acute levodopa test)
• Brain MRI without abnormality
• Normality of biological examinations
• Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent)
• Patient with social health insurance

Criteria for non-inclusion of Parkinsonian patients who will be operated

• Contraindication to examinations necessary for inclusion
• Evolutionary psychiatric pathology;
• Dementia(MMS<24/30);
• Patients with a medical condition that makes surgery dangerous neuro-surgical;
• Bleeding-promoting diseases and laboratory test abnormalities clotting;
• Existence of contraindications to MRI (cardiac or neural pacemaker, clips ferromagnetic surgeries, implants and metal objects, foreign bodies intraocular, pregnancy, claustrophobia).
• Taking drugs interfering with coagulation for 1 month before intervention.
• Persons under guardianship, curatorship or any other administrative or judicial measure deprivation of rights and liberty

Selection criteria for non-operated patients

• Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank);
• Age between 18 and 70;
• Other medical conditions that are stable or do not interfere with the proposed protocol;
• Presence of axial signs (gait and/or balance disorders) no improved by antiparkinsonian treatment
• Brain MRI without notable abnormality
• Normality of biological examinations
• Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent)
• Patient with social health insurance

Criteria for non-inclusion of non-operated patients

• Contraindication to examinations necessary for inclusion
• Progressive psychiatric pathology;
• Dementia (MMS<24/30);
• Existence of contraindications to MRI (cardiac or neural pacemaker, clips ferromagnetic surgeries, implants and metal objects, foreign bodies intraocular, pregnancy, claustrophobia).
• Persons under guardianship, curatorship or any other administrative or judicial measuredeprivation of rights and liberty

Inclusion criteria

for group 3 patients (already operated)

• Diagnosis of idiopathic Parkinson's disease (according to the criteria of the United Kingdom Parkinson's Disease Society Brain Bank);
• Bilateral deep brain stimulation of the subthalamic nucleus for more than 1 year
• Age between 18 and 70;
• Person who has voluntarily and informedly agreed to participate in the study (signature of a written consent)
• Patient with social health insurance

Criteria for non-inclusion of Parkinsonian patients (already operated)

• Contraindication to examinations necessary for inclusion
• Evolutionary psychiatric pathology;
• Dementia(MMS<24/30);
• Persons under guardianship, curatorship or any other administrative or judicial measure deprivation of rights and liberty

Inclusion criteria

for healthy subjects

• Age between 18 and 70 years old
• Normal neurological examination
• Person who voluntarily and informedly agreed to participate in the study (signature of a written consent)
• Patient with social health insurance

Criteria for non-inclusion of healthy subjects

• Persons under guardianship, curatorship or any other administrative or judicial measure of deprivation of rights and freedom
• Existence of neurological, orthopedic or psychiatric history
• Existence of contraindications to MRI (cardiac or neural pacemaker, ferromagnetic surgical clips, implants and metallic objects, foreign bodies intraocular, pregnancy, claustrophobia).