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Completed

NCT Number: NCT01888991

Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men

The purpose of this study is to investigate the effect of substrate oxidation, expressed by RER, on food intake regulation and net energy balance.

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Key information

Conditions

Food Intake Regulation Behavior Motor Activity Substrate Oxidation

Age range

9 year–29 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Department of Nutritional Sciences, University of Toronto

Toronto, Ontario, M5S 3E2, Canada

About this study

The relationship between substrate oxidation as measured by respiratory exchange ratio (RER) and food intake is undefined. This study is examining the effects of three modulators of substrate oxidation (RER), a glucose preload, exercise and age food intake regulation and net energy balance in normal-weight boys (9-12 y) and men (20-30 y).

Subjects (15 boys, 15 men) were measured in random order with treatments of beverages of either water or glucose followed by either moderate exercise or rest for 40 min. Measures included RER via indirect calorimetry, energy expenditure, subjective appetite, food intake measured at an ad libitum pizza meal and net energy balance as the sum of the calories of the glucose preload + calories from the pizza lunch minus energy expended at exercise or rest.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Born at full term
  • Men Age:20-29 years/BMI: 20-25
  • Boys Age 9-11/BMI percentile: 15th to 85th:

Exclusion criteria

  • Smokers
  • Dieters
  • Individuals with lactose intolerance, allergies to milk and dairy products
  • Individuals with gastrointestinal problems
  • Individuals with diabetes or other metabolic diseases
  • Individuals scoring ≥ 11 on an Eating Habit Questionnaire

Treatment and study plan

Glucose Preload and Exercise Intervention

Other

A glucose preload and exercise were administered to examine the modulate substrate oxidation

Primary outcomes

  1. Food Intake

    Time frame: 60 - 90 min in the study

    Energy intake from the ad libitum the pizza meal at 60 min was calculated based on the weight consumed and the compositional information provided by the manufacturer.

Secondary outcomes

  1. Net Energy Balance

    Time frame: 0-90 min in the study

    Will be calculated from the energy consumed by the glucose preload and the pizza meal minus energy expended at the exercise.

Sponsors and collaborators

Lead sponsor

University of Toronto

Other

Collaborators

  • Canadian Institutes of Health Research (CIHR)

Registry information

Official study title

Substrate Oxidation Does Not Affect Short Term Food Intake in Healthy Boys and Men.

Important dates

Study start
2011
Primary completion
2012
Study completion
2012
First posted
Jun 28, 2013
Registry last updated
Jun 28, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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