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Completed

NCT Number: NCT01943812

Substituted Frozen Embryo Transfer Cycles With GnRH-agonist Supplementation

The aim of this study is to compare two FET protocols by modifying the substituted FET cycle in order to maintain a higher ongoing positive pregnancy rate and thus reduce the early pregnancy loss.

Hypothesis: adding GnRH-agonist to the substituted cycle in FET treatment reduces the early pregnancy loss.

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Key information

Conditions

Pregnancy Loss Frozen Embryo Transfer

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 4

Primary location

IVF syd, Fredericia, Denmark

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Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Endometrial thickness ≥ 7 mm after stimulation
  • 18-45 years
  • IVF/ICSI fertilisation
  • BMI > 18,5 <30 kg/m2
  • cycle length 25-34 days

Exclusion criteria

  • endometrial thickness < 7 mm or no triple layer endometrium and/or functional follicles
  • Uterine abnormality
  • Chronic medical disease
  • oocyte donation cycles

Treatment and study plan

Estradiol and progeterone

Drug

Estradiol and progesterone

Other names: Estradiol and progesterone

Primary outcomes

  1. Pregnancy loss rate

    Time frame: Primary outcome is avaible after 12th week of gestational.

Secondary outcomes

  1. Pregnancy rate

    Time frame: 14 days after embryo transfer.

Other outcomes

  1. Luteal progesterone levels

    Time frame: 7th week of gestation

Sponsors and collaborators

Lead sponsor

Peter Humaidan

Other

Registry information

Important dates

Study start
2013
Primary completion
2019
Study completion
2020
First posted
Sep 17, 2013
Registry last updated
Jun 23, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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