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NCT Number: NCT07070414

Substance Use in Assault-Injured Young Adults

This study aims to improve a short motivational conversation to better help young adults who were injured in assaults and also use alcohol or cannabis. Researchers will gather both interview and survey data from young adults who came to the emergency department after an assault and currently use alcohol or cannabis. Guided by a theory about risky behaviors, the study will focus on how confident young people feel about making changes to their alcohol and cannabis use, and how their friends and family influence their alcohol and cannabis use and involvement in injuries from assault. The team will follow a step-by-step process used by the NIH to adapt and test the improved motivational conversation in the emergency department.

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Key information

Conditions

Alcohol Misuse Cannabis Misuse

Age range

18 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Yale Department of Emergency Medicine

New Haven, Connecticut, 06520, United States

About this study

Aim 1: Quantitatively and qualitatively assess self-efficacy, perceived peer and familial norms, and motivation to reduce alcohol and/or cannabis use and engage in treatment referral, among assault-injured emerging adults. AIM 2: Adapt the BNI for use among assault-injured emerging adults with alcohol and/or cannabis misuse in the ED. AIM 3: Determine the feasibility and acceptability of an adapted BNI among assault-injured emerging adults with alcohol and/or cannabis misuse presenting to the ED through a randomized pilot trial comparing those who have received the adapted BNI and treatment referrals to a referrals-only control group. The focus of this registration is the randomized pilot in Aim 3. Anticipated start dates will be reflected in the clinical trial component in Aim 3.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aim 1:

  • Be clients of the Yale Hospital Violence Intervention Program (YHVIP)
  • Be between the ages of 18-25 y/o upon study enrollment
  • Have sustained an intentional injury inflicted by another person not considered to be a boy/girlfriend, fiancée, or spouse in the past year
  • Report current alcohol and/or cannabis misuse
  • Be English-speaking and able to provide informed consent.

Aim 2 and 3:

  • Present to Yale New Haven Hospital ED for an intentional injury inflicted by another person not considered to be a boy/girlfriend, fiancée, or spouse
  • Be between the ages of 18-25 y/o upon study enrollment
  • Report current alcohol and/or cannabis misuse
  • Be English-speaking and able to provide informed consent.

Exclusion criteria

Aim 1:

  • Be actively suicidal or severely cognitively impaired precluding informed consent
  • Sustain an intentional injury from a boy/girlfriend, fiancée, or spouse or sexual assault
  • Be incarcerated or in police custody
  • Currently engaged in addiction treatment

Aim 2 and 3:

  • Be actively suicidal or severely cognitively impaired precluding informed consent
  • Sustain intentional injury from a boy/girlfriend, fiancée, spouse or by sexual assault
  • Be incarcerated or in police custody
  • Currently engaged in addiction treatment

Treatment and study plan

Brief Negotiation Interview intervention (BNI) (adapted)

Behavioral

A brief motivational interview designed to increase motivation to reduce alcohol and/or cannabis use and engagement in treatment referral.

Primary outcomes

  1. Feasibility assessed by recruitment

    Time frame: Day 0 and 30

    Recruitment measured as the percentage of those invited/those who enrolled

  2. Feasibility assessed by randomization

    Time frame: Day 0 and 30

    Recruitment measured as the percentage of screened eligible participants who enroll/those who receive either intervention or control arm

  3. Feasibility assessed by retention

    Time frame: Day 0 and 30

    Recruitment measured as the percentage of those enrolled who have received either intervention or control arm/ participants who have completed all 30-day follow up assessments

  4. Acceptability assessed by Acceptability of Intervention Measure (AIM)

    Time frame: Day 0

    Acceptability of the intervention will be assessed using the Acceptability of Intervention Measure (AIM). It has 4-items scored on a 5-point Likert scale summed to achieve a total score. Total score range of 0-20. Higher scores indicate more acceptability.

Study contacts

Contact information is provided by the study sponsor or research team.

Edouard Coupet Jr., MD, MS

CONTACT

[email protected]

(203) 584-9445

Sponsors and collaborators

Lead sponsor

Yale University

Other

Collaborators

  • National Institute on Drug Abuse (NIDA)

Registry information

Official study title

Alcohol and Cannabis Use Among Assault-Injured Emerging Adults

Important dates

Study start
2027
Primary completion
2028
Study completion
2028
First posted
Jul 17, 2025
Registry last updated
Jun 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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