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Completed

NCT Number: NCT06244693

SUbCONgestion in Heart Failure Registry

The goal of this observational study is to learn about the decongestion process in heart failure patients. The main question it aims to answer is: What is the behavior of congestion during hospitalization in adult patients with acute heart failure (AHF)? Participants will be evaluated in the decongestion process through clinical, analytical, and ultrasonographic variables, and they will be followed up for one year to assess mortality and rehospitalization rates in this population.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Departamento Cardiovascular - Hospital Clínico Universidad de Chile

Santiago, Metropolitan, 8380456, Chile

About this study

Heart failure (HF) is a syndrome characterized by the presence of dyspnea, lower extremity edema, orthopnea, jugular venous distention, and pulmonary crackles, among others, secondary to elevated ventricular filling pressures. It is the leading cause of hospitalization in medical services in Chile and worldwide, with the majority of patients being elderly. Decompensation of HF is explained in most cases by fluid overload (congestion) and can be studied through biomarkers, clinical signs, radiographic, and ultrasonographic findings. The Chilean demographic transition makes it necessary to optimize the multiparametric and protocolized management of hospitalized patients.

General Objective: To evaluate and describe the decongestion process, including residual congestion, during hospitalization for heart failure at the Clinical Hospital of the University of Chile (HCUCh).

A prospective observational cohort study will be conducted with all patients hospitalized for heart failure at HCUCh. Clinical, analytical, and ultrasonographic variables, especially those related to congestion assessment, will be recorded. Enrollment will last for one year from institutional authorization, and telephone follow-up will be conducted for one year post-discharge, extendable up to five year.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults diagnosed with decompensated heart failure in the emergency department or cardiology outpatient clinic at the Clinical Hospital of the University of Chile (HCUCh).
  • Profile of warm-wet and cold-wet type heart failure.
  • Spontaneous ventilation with or without non-invasive mechanical support.
  • Desire for participation validated through informed consent.

Exclusion criteria

  • Dry-type heart failure profile (warm and cold)
  • Diagnostics that mimics heart failure (valvular heart disease, cardiomyopathies, and others diagnostic different from heart failure).
  • Septic, distributive, or obstructive shock
  • Polytraumatized
  • Severe burns
  • Invasive mechanical ventilation
  • Permanent renal replacement therapy
  • Severe dependence
  • Presence of terminal illness with a prognosis of survival less than one year
  • Presence of traumatic conditions that prevent the use of thoracic ultrasound, such as a flail chest or moderate to severe burn on the left hemithorax.
  • Lack of a support network or contact.
  • Cardiorespiratory arrest
  • Refusal to participate as indicated in the informed consent.
  • Presence of psychological or intellectual disability that prevents expressing the will to participate.

Treatment and study plan

No intervention

Other

No intervention

Primary outcomes

  1. Rehospitalization

    Time frame: One year from discharge

    Readmission to hospital for cardiac cause

  2. All cause mortality

    Time frame: One year after discharge

    Death from any cause

Secondary outcomes

  1. Cardiac death

    Time frame: One year after discharge

    Death form cardiac cause

Sponsors and collaborators

Lead sponsor

University of Chile

Other

Registry information

Official study title

Description and Analysis of Congestion During Hospitalization for Acute Decompensated Heart Failure

Acronym: SUCONIC

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Feb 6, 2024
Registry last updated
May 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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