Subclassification of the Syndrome of Inappropriate ADH Secretion

The aim of this study is to evaluate the different types of osmotic dysregulation in patients with Syndrome of Inappropriate ADH (SIADH) and, hence, to analyze the pathophysiology of SIADH.

These types will be characterized by measurement of AVP and copeptin while performing an osmotic stimulation with infusion of hypertonic saline.

Completed

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Key information

Conditions

Hyponatremia Brain Diseases Central Nervous System Diseases Diabetes Insipidus Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Hypothalamic Diseases Inappropriate ADH Syndrome Kidney Diseases Male Urogenital Diseases Metabolic Diseases Nervous System Diseases Nutritional and Metabolic Diseases Pituitary Diseases Urogenital Diseases Urologic Diseases Water-Electrolyte Imbalance

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Wuerzburg

Würzburg, Bavaria, 97080, Germany

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

age > 18 years,
hyponatremia < 132 mmol/L
SIADH

Exclusion criteria

age < 18 years
cerebral metastases
serum sodium > 132mmol/L

Sponsors and collaborators

Lead sponsor

University of Wuerzburg

Other

Registry information

Official study title

Subclassification of the Syndrome of Inappropriate Antidiuresis Via Copeptin - What is the Genesis of ADH-independent SIADH?

Important dates

Study start: 2008
Primary completion: 2011
Study completion: 2011
First posted: Apr 26, 2011
Registry last updated: Apr 26, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed