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OpenTrials
Completed

NCT Number: NCT03206034

Stylistic Memory Enhancement

Impairments in higher level cognitive processing, such as new learning and memory, are common in Multiple Sclerosis (MS) and negatively impact multiple aspects of everyday life, including occupational and social functioning. Despite this, few studies have attempted to remediate these cognitive deficits in order to improve everyday functioning. While not applied in traditional rehabilitation protocols as of yet, many techniques from cognitive psychology significantly improve learning and memory in healthy persons. These techniques include the generation effect (GE), the spacing effect (SE), and the testing effect (TE). These techniques have recently been incorporated into an 8-session treatment protocol, Stylistic Memory Enhancement (SME), designed to teach participants about each of the techniques, train them on how to apply the techniques in daily life and practice their application to daily life memory demanding situations. The protocol includes teaching participants how to restructure a memory demanding situation in order to make optimal use of self-generation, spaced learning and self-testing. The objective of the study is to test the efficacy of the SME in an MS population.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Clinically definite MS between the ages of 18 and 59. Participants must have impairment in new learning (determined by an in-person screen) with intact language comprehension.

Exclusion criteria

  • History of alcohol or drug abuse/dependence,
  • Major psychiatric disturbance (e.g. bipolar disorder, schizophrenia) and neurological history other than MS.
  • Corticosteroid use within the last month prior to the participation.
  • Less than 1 month post most recent exacerbation.

Treatment and study plan

Stylistic Memory Enhancement

Behavioral

Primary outcomes

  1. California Verbal Learning Test (CVLT-II- Total learning

    Time frame: Baseline and post-intervention (5 weeks between testing sessions)

    Measure of change in new learning

Secondary outcomes

  1. Memory Functioning Questionnaire

    Time frame: Baseline and post-intervention ( 5 weeks between testing sessions)

    Measure of change in Self-report of everyday memory functioning

Sponsors and collaborators

Lead sponsor

Kessler Foundation

Other

Registry information

Acronym: SME

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Jul 2, 2017
Registry last updated
Jul 2, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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