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Completed

NCT Number: NCT01430637

Studying Genes in Samples From Younger Patients With Desmoplastic Small Round Cell Tumor Registered on COG-D9902 or COG-ABTR01B1

RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research study is studying genes in samples from younger patients with desmoplastic small round cell tumor registered on COG-D9902 or COG-ABTR01B1.

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Key information

Conditions

Sarcoma Desmoplastic Small Round Cell Tumor Neoplasms Neoplasms by Histologic Type Neoplasms, Connective and Soft Tissue

Age range

Up to 50 year

Sex eligibility

All sexes

Study type

Observational

About this study

OBJECTIVES:

  • To perform whole-exome sequencing on desmoplastic small round cell tumor (DSRCT) samples and their available matched normal samples to identify novel mutations, single nucleotide polymorphisms, or copy number changes associated with these tumors.
  • To identify regions of interest that may be involved in the pathogenesis (including the region of EWSR1-WT1 translocation) from the whole-exome sequencing and perform detailed resequencing and transcriptone sequencing to further define the molecular aberrations at the RNA level.

OUTLINE: This is a multicenter study.

Archived tumor tissue samples are analyzed for DNA sequencing, effects of RNA on gene expression levels, novel RNA isoforms, splice variants, and translocations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

DISEASE CHARACTERISTICS:

  • Tumor and blood samples from patients registered on COG-D9902 or COG-ABTR01B1 obtained from the Cooperative Human Tissue Network (CHTN) and the Children's Oncology Group (COG) tumor banks
  • Matched normal samples

PATIENT CHARACTERISTICS:

  • Not specified

PRIOR CONCURRENT THERAPY:

  • Not specified

Treatment and study plan

DNA analysis

Genetic

RNA analysis

Genetic

gene expression analysis

Genetic

mutation analysis

Genetic

nucleic acid sequencing

Genetic

polymerase chain reaction

Genetic

laboratory biomarker analysis

Other

Pharmacogenomic studies

Other

Primary outcomes

  1. Identification of novel mutations, single nucleotide polymorphisms, and copy number changes associated with DSRCT

  2. Identification of genomic regions involved in pathogenesis of DSRCT

Sponsors and collaborators

Lead sponsor

Children's Oncology Group

Network

Collaborators

  • National Cancer Institute (NCI)

Registry information

Official study title

Comprehensive Genome Sequencing of Desmoplastic Small Round Cell Tumors

Important dates

Study start
2011
Primary completion
2016
First posted
Sep 8, 2011
Registry last updated
May 18, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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