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OpenTrials
Completed

NCT Number: NCT04227717

Studying a New Piece of Equipment That Can Help Plan Radiation Therapy of the Spine

Participants will receive an MRI with a custom-built MRI coil for each participant. The purpose is to find out whether this custom-built MRI coil can help doctors see the different parts of the spine as well as or better than they can with standard CT myelograms.

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Key information

Conditions

Thoracic Cancer Bone Diseases Central Nervous System Diseases Central Nervous System Neoplasms Musculoskeletal Diseases Neoplasms Neoplasms by Site Nervous System Diseases Nervous System Neoplasms Respiratory Tract Diseases Spinal Cord Diseases Spinal Cord Neoplasms Spinal Diseases Spine Cancer Spine Disease Spine Metastases Thoracic Diseases Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Memorial Sloan Kettering Cancer Center

New York, 10065, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • >/= 18 years of age at the time of treatment
  • Able to give informed consent
  • Consented for spine stereotactic radiation therapy
  • No contraindications for CT myelograms which include:
  • Allergy to CT contrast
  • Use of phenothiazines
  • Platelet count < 60,000 K/mcl
  • INR > 1.5
  • VEGF inhibitor use in the past 2 weeks prior to myelogram
  • NSAID use in the past 5 days prior to myelogram
  • Renal disease
  • Creatinine > 1.2 mg/dL
  • No contraindications for MRI scans which include:
  • Newly placed glucose monitors
  • Tattoos (Tattoos for radiation therapy are allowed)
  • Presence of a cardiac pacemaker
  • Presence of an implanted cardioverter defibrillator
  • Breast tissue expander
  • Aneurysm clip
  • Any other implanted metallic (BB, bullet, shrapnel, IUD, metallic stent or filter, spinal cord simulator etc.) or electronic device which is considered MR unsafe
  • Severe claustrophobia or inability to lie flat for the duration of the study, etc.

Exclusion criteria

  • Presence of surgical spine hardware at the region of interest
  • Presence of cervical spine lesions
  • History of claustrophobia

Treatment and study plan

MRI with custom MRI spine coil

Diagnostic Test

Participants will undergo MRI with custom MRI spine coil

Primary outcomes

  1. Difference of calculated doses to the cauda equine and spinal cord based upon MRI coil vs CT myelogram used to define each structure

    Time frame: 6 months

    The calculated doses to the cauda equine and spinal cord will be compared and evaluated for significant difference based upon the imaging modality (MRI coil vs CT myelogram) used to define each structure, with all other target and avoidance volumes being equal in the same patient.

Sponsors and collaborators

Lead sponsor

Memorial Sloan Kettering Cancer Center

Other

Registry information

Official study title

Assessment of a Custom-Built MRI Coil for Spine Radiotherapy Treatment Planning

Important dates

Study start
2020
Primary completion
2025
Study completion
2025
First posted
Jan 14, 2020
Registry last updated
Jul 18, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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