Study to Investigate the Potential Pharmacological Effect of Oral Palmitoylethanolamide (PEA) Therapy in the Management of Low Back Pain (Neuropathic Pain)

Neuropathic low back pain arises from nerve damage or dysfunction, leading to chronic pain characterized by burning, tingling, or shooting sensations. This condition significantly impacts quality of life and is often refractory to conventional treatments. Palmitoylethanolamide (PEA) is an endogenous lipid mediator known for its anti-inflammatory, analgesic, and neuroprotective properties. PEA exerts its effects by modulating the endocannabinoid system and reducing the activation of mast cells and glial cells, which play a crucial role in chronic pain mechanisms. Its potential as a therapeutic agent for neuropathic pain has been demonstrated in preclinical and clinical studies, making it a promising candidate for managing neuropathic low back pain.

In the present randomized, double-blind, placebo-controlled, parallel-group clinical trial, the investigators aim to evaluate the therapeutic effect of a novel bioavailable oral formulation of PEA's Phytosome® in the management of neuropathic low back pain in healthy adult population.

Inclusion criteria

• Healthy adults, both Male or female aged ≥ 18 years and ≤ 80 years;
• Diagnosed with neuropathic lower back pain for at least 3 months, as confirmed by clinical evaluation and DN4 (neuropathic pain 4 questions) screening questionnaire with score ≥4.
• Pain intensity score ≥ 5 measured by NRS (Numerical Rating Scale) score, over the past week.
• Willingness to adhere to study protocol, including visits, assessments, and self-reporting of symptoms.
• Ability to provide informed consent and comply with study requirements.

Exclusion criteria

• Known intolerance or allergy to any component of the tested nutraceuticals
• Presence of acute systemic disease
• Presence of significant organic pathology
• Current or past history of alcohol or drug abuse
• History of malignancy within the past 5 years
• Any significant concomitant disease or clinical condition that could compromise participant safety or interfere with study completion
• Women of childbearing potential not using reliable contraceptive methods
• Pregnancy or breastfeeding
• Severe psychiatric disorders (e.g., major depression, schizophrenia) that could affect pain perception or adherence.
• Inability to adhere to the study requirements due to lifestyle, transportation, or cognitive impairment.
• Use of other cannabinoid-based therapies, investigational drugs, or concurrent participation in another clinical trial.
• Dependence on opioid analgesics or recent opioid use that may interfere with pain assessment.
• Current use of other supplements with potential anti-inflammatory or analgesic effects, including Omega-3 Fatty Acids, Turmeric/Curcumin, Glucosamine and Chondroitin, Boswellia Serrata, Methylsulfonylmethane.