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OpenTrials
Completed

NCT Number: NCT02093611

Study to Examine the Effects of ATP Supplementation on Muscle Excitability and Reaction Time During and Following a Repeated Sprint Bout

We hypothesize that adenosine-5'-triphosphate (ATP) supplementation will be able to enhance motor unit recruitment while simultaneously blunting the decline in power and reaction time that is typically seen during repetitive sprints. This will give researchers a better understanding of the mechanism by which ATP supplementation can augment power, especially under high fatiguing conditions.

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Key information

Conditions

Muscle Fatigue Caused by Repetitive Muscle Exercise

Age range

18 year–30 year

Sex eligibility

Male

Study type

Interventional

Phase

Not applicable

Primary location

Jacob M Wilson, PhD

Tampa, Florida, 33606, United States

About this study

Healthy participants of similar training status as previously tested will be enrolled into the study. The participants will be randomly assigned to either placebo supplementation or to 400 mg ATP per day for 14 days. The supplements will be taken in the morning and the last dose will be taken 30 min prior to testing on the last day. Testing will be performed at baseline and after the 14 days of supplementation. Ten successive sprints will be conducted on the Wingate apparatus as this has been previously demonstrated to decrease muscle excitability. After the sprints, muscle excitability, reaction time, and vertical jump power will be measured. In addition a blood sample will be obtained before and after supplementation and complete blood hematology and chemistry analyses will be performed. It is expected that ATP supplementation may help maintain muscle excitability and power after the successive sprint sessions.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat.
  • Must not have taken performance enhancing supplements for at least 3 months prior to the study start,
  • Must be a non-smoker.
  • Must not be taking amino acid supplements.
  • Must not be using anabolic or catabolic hormones.
  • Must not be taking any medications known to influence variables to be measured in the study.

Exclusion criteria

  • Will not agree to eating a diet approved by a registered dietician consisting of the following by caloric percentages: 15-20% protein, 44-55% carbohydrate, and 25-30% fat.
  • Has taken performance enhancing supplements for at least 3 months prior to the study start,
  • Is currently a non-smoker.
  • Is currently taking amino acid supplements.
  • Is currently using anabolic or catabolic hormones.
  • Is currently taking medications known to influence variables to be measured in the study.

Treatment and study plan

Placebo

Dietary Supplement

Other names: Placebo Comparator

ATP

Dietary Supplement

400 mg of ATP

Other names: Peak ATP

Primary outcomes

  1. Muscle Excitability

    Time frame: Day 14

    Muscle excitability will be measured using Delsys Wireless Electromyography (EMG) sensors.

Secondary outcomes

  1. Power

    Time frame: Day 14

    Muscle power will be measured using the Wingate and vertical jump power measures.

Other outcomes

  1. Reaction Time

    Time frame: Day 14

    Reaction time will be measured using a Dynavision apparatus.

  2. Blood Biochemical Analyses

    Time frame: Day 14

    Blood chemistries and hematology will be measured after the 14 days of supplementation.

Sponsors and collaborators

Lead sponsor

Metabolic Technologies Inc.

Industry

Collaborators

  • University of Tampa

Registry information

Important dates

Study start
2013
Primary completion
2015
Study completion
2015
First posted
Mar 21, 2014
Registry last updated
Sep 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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