Study to Evaluate the Safety, Tolerance, Pharmacokinetics and Preliminary Efficacy of IBI346#CIBI346Y001#

Inclusion criteria

• According to the multiple myeloma diagnostic criteria of the International Myeloma Working Group (IMWG), there is the initial diagnosis of multiple myeloma.
• Subjects must have previously received at least 3 anti-myeloma regimens. Subjects must have documented disease progression (according to IMWG criteria) during or within 12 months of completing their last anti-myeloma regimen prior to study entry; and prior regimens must have included proteasome inhibitor (PI) and immunomodulatory drug (IMiD).
• Measurable disease as defined by the protocol
• ECOG score is 0 or 1.
• Expected survival time ≥12 weeks.

Exclusion criteria

• Patients suffering from graft-versus-host disease (GVHD) or requiring immunosuppressants drugs.
• Patients who received autologous hematopoietic stem cell transplantation (ASCT) or prior allogeneic hematopoietic stem cell transplantation (ALLo-HSCT) within 12 weeks prior to mononuclear cell collection.
• No unmobilized mononuclear cells can be collected for CAR T cell production.
• Screening subjects who were receiving systemic steroids during the previous 7 days or who were determined by the investigator to require long-term systemic steroid use during treatment (except for inhaled or topical use, except at doses < 10mg/ day).
• Patients with a history of hypertension that cannot be controlled by medication (blood pressure ≥140/90 mmHg).