Study to Evaluate the Safety, Tolerability and the Effect of BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects With Mild Alzheimer's Disease

Inclusion criteria

• Mild AD Subjects meeting National Institute of Neurological Disorders and Stroke - Alzheimer's Disease Related Disorders Association(NINCDS-ADRDA) and Diagnostic and Statistical Manual of Mental Disorders-Forth Edition, Text Revision (DSM-IV-TR) criteria
• Mini-Mental State Exam (MMSE) Score between 20 & 26 (inclusive)
• CSF consistent with AD pathology
• Screening brain MRI - normal - commensurate with age or demonstrate atrophy consistent with AD diagnosis (dx); reveal no more than mild white matter disease; up to 2 lacunar infarcts acceptable except in anterior thalamus, genu of internal capsule or basal forebrain; reveal no cortical infarcts; reveal no more than 4 microbleeds; reveal no focal asymmetric lobar atrophy or other findings suggesting primary cause of dementia is attributed to a cause other than AD; reveal no macrohemorrhages (>10 mm)
• Subjects must have reliable study partners
• Men and Women of Non Child Bearing Potentia (WONCBP), ages 50-90 years

Exclusion criteria

• Subjects with any other medical condition other than mild AD that could explain subjects' memory or cognitive deficits
• Subjects diagnosed with moderate or severe AD per DSM-IV criteria
• Subjects with a history (hx) of stroke
• Subjects with a hx of GI illnesses
• Subjects with Vitamin B12 or folate deficiency
• Subjects with any unstable cardiovascular (CV), pulmonary, Gastrointestinal (GI) or hepatic disease within 30 days prior to screening
• Subjects with active liver dx or history of hepatic intolerance
• Subjects with a Geriatric Depression Scale score of ≥ 6 at screening
• Subjects treated for or have had a diagnosis of schizophrenia
• Subjects treated for or have had a diagnosis of bipolar disease within 3 years prior to screening
• Subjects with a history of generalized peripheral neuropathy