Study to Evaluate the Impact of Obesity on Airway Inflammation and Mechanics in Asthmatics

In the United States there has been a dramatic increase in the number of people who are obese and in the number of people who have asthma. Both are considered serious public health concerns. Several studies have shown that becoming obese or overweight can increase the risk of developing asthma or can make asthma symptoms more severe and difficult to control. How obesity affects asthma is not fully understood. This research study will examine whether obesity affects the amount of inflammation that is present in the lungs of people with asthma, and will also examine whether obesity leads to narrow and stiff airways.

Participation in this study involves 2 visits in order to complete questionnaires, various pulmonary function tests, as well as the collection of blood, urine, and exhaled breath condensate specimens.

This research study includes optional genetic and bronchoscopy substudies.

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Key information

Conditions

Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year–70 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Emory University, Emory Crawford Long Hospital, Clinical Research Center

Atlanta, Georgia, 30308, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Adults 18 to 70 years of age
If asthmatic, currently taking a short acting beta agonist and an inhaled corticosteroid
Never smoked or limited smoking history

Exclusion criteria

Current upper respiratory illness (other than asthma)
Illegal drug use within past month
Consumption of more than 6 alcoholic drinks per week
Active, pronounced rhinitis or sinusitis
Pregnancy
Currently taking oral steroids or steroid injection over the past month
Asthma exacerbation over the past month
Certain medical illnesses

Treatment and study plan

No intervention

Other

no intervention

Sponsors and collaborators

Lead sponsor

Emory University

Other

Collaborators

Critical Therapeutics

Registry information

Acronym: ABI/BALA

Important dates

Study start: 2005
Primary completion: 2008
Study completion: 2008
First posted: Feb 14, 2008
Registry last updated: Sep 23, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed