Study to Evaluate How Patients Regard the Benefits and Risks of Low-dose Aspirin for the Prevention of Heart and Blood Vessels Disease and for the Prevention of Cancer of the Colon and Rectum

Patient Eligibility Criteria

Inclusion criteria

• Age and CVD characteristics

• Primary prevention:

• 50-70 years of age
• Self-report clinical characteristics that result to 20% or higher, 10-year risk of CVD based on the Progetto Cuore scores
• Secondary prevention:

• 18 years or older
• Having a self-reported history of CV event (e.g., myocardial infarction (MI), ischaemic stroke or Transient Ischaemic stroke, , and angina)
• Able to read and understand Italian
• No participation in an investigational program with interventions outside of routine clinical practice
• For qualitative interviews:

• Willing and able to provide (electronic) informed consent to participate in the study
• Willing and able to participate in a telephone interview, and to be audio-recorded
• For pilot/cognitive interviews :

• Willing and able to complete an online survey
• Willing and able to provide (electronic) informed consent to participate in the study
• Willing and able to participate in an in-person interview, and to be audio-recorded
• For quantitative main survey:

• Willing and able to complete an online survey
• Willing and able to provide (electronic) informed consent to participate in the study

Exclusion criteria

• Have glucose-6-phosphate dehydrogenase (G6PD) deficiency (which commonly causes haemolytic anaemia, which is often triggered from eating fava beans, a condition called Favism)
• Have the following conditions (which are contraindications to low-dose aspirin)

• Known hypersensitivity to salicylates
• Known to have had asthma induced by salicylates
• Having been diagnosed with acute gastroduodenal ulcers
• Haemorrhagic diathesis
• Renal failure
• Hepatic failure
• Concomitant treatment with methotrexate
• Cognitive impairment, hearing difficulty, visual impairment, acute psychopathology, or insufficient knowledge of Italian that-in the opinion of the investigator/interviewer-could interfere with a patient's ability to provide written consent and complete an interview or survey
• To be currently pregnant
• Are pharmaceutical company employees or employed in a position where they have a direct role in treating patients with CVD

Physician Eligibility Criteria:

• A medically trained physician
• Able to read, speak, and understand Italian sufficiently to complete an interview
• Able to provide informed consent electronically
• Have at least five year experience prescribing low-dose aspirin for primary and secondary prevention of CVD
• Willing to be audio-recorded, including adherence to the interview instructions