Study to Characterize the Pharmacokinetics and Safety of TV-45070 Ointment in Healthy Volunteers

Inclusion criteria

• Healthy male and/or female subjects aged 18 to 50 years
• Body Mass Index (BMI) ≥18.0 and ≤32.0 kg/m2.
• Able and willing to provide written informed consent.
• Able and willing to comply with all study procedures and restrictions.

Exclusion criteria

• History or evidence of clinically significant illness or surgery
• Presence of open wounds, sunburn, tattoo, major scarring, non-intact or damaged in the proposed application area that would interfere with the application of the study drug treatments or biopsies.
• History of significant drug or alcohol abuse
• Use of prescription drugs within 30 days or 5 half-lives (whichever is longer) prior to Day 1.
• Use of topical application of an OTC medicated or prescription medication or other skin creams/ointments (eg, moisturizers, balms) in the areas intended for study drug administration within 7 days prior to Day 1. Use of topical capsaicin within 6 months prior to Day 1.
• Pregnant or nursing females
• Shaving or waxing the planned study treatment application area within 7 days prior Day 1.
• Laser hair removal of the planned study treatment application area within 2 months prior to Day 1.

• other criteria apply, please contact the investigator for more information